Korean J Med.  2008 Jul;75(1):88-92.

A case of lymphoplasmacytic sclerosing pancreatitis with pancreatic adenocarcinoma

Affiliations
  • 1Department of Internal Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea. hongjoo3.kim@samsung.com
  • 2Department of Diagnosic Pathology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.

Abstract

Lymphoplasmacytic sclerosing pancreatitis (LPSP) is a rare entity that has been described under many different names; LPSP is an autoimmune form of chronic pancreatitis. LPSP may simulate a neoplastic process both clinically and radiologically. We report a case of LPSP with pancreatic adenocarcinoma. A 70-year-old woman was admitted to our hospital for evaluation of pancreatic duct dilatation. The CA 19-9 level was normal and the antinuclear antibody titer was negative. An abdominal CT revealed a low density nodule, 8 mm in size, in the body of the pancreas with parenchymal atrophy and mild dilatation of the main pancreatic duct in the body and tail portion. Endoscopic retrograde cholangiopancreaticography demonstrated a stricture of the main pancreatic duct in the body of the pancreas and mild dilatation of the upstream duct. She underwent subtotal pancreatectomy and splenectomy. The results of the pathologic examination of the resected tissue included pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia in the background of lymphoplasmacytic sclerosing pancreatitis.

Keyword

Lymphoplasmacytic sclerosing pancreatitis; Adenocarcinoma; Autoimmune pancreatitis
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