Korean J Med.  2008 Nov;75(5):496-502.

Diagnosis and treatment of Helicobacter pylori infection in patients treated with non-steroidal anti-inflammatory drugs

  • 1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.


Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory drugs (NSAIDs) are well-established causes of gastrointestinal mucosal damage, such as uncomplicated and complicated peptic ulcer diseases. Many epidemiologic studies suggest that H. pylori infection increases the risk of developing peptic ulcer complications among non-aspirin NSAID consumers. According to data from randomized clinical trials, H. pylori eradication may prevent NSAID-induced ulcers in non-aspirin NSAID-naive patients and long-term aspirin consumers with a history of ulcer complications. H. pylori eradication by itself is insufficient to prevent NSAID-induced peptic ulcers and complications among low-risk NSAID consumers. In patients receiving long-term non-aspirin NSAIDs with a history of ulcer complications, proton pump inhibitor is more effective in preventing ulcer recurrence and bleeding.


Helicobacter pylori; Anti-Inflammatory agents; Non-steroidal; Peptic ulcer
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