Korean J Nephrol.  1997 Dec;16(4):820-823.

A Case of Acute Renal Failure Due to Ingestion of Silicon Compound

• Chun MY
• Park DJ
• Lee SS
• Park BG
• Lee JD
• Jung YT
• Hwang JY
• Chang SH
• Jung SI
• Go KH

Abstract

Excessive exposure to several metallic elements is known to produce a variety of nephrotoxic syndromes such as glomerulonephritis, nephrotic syndrome, interstitial nephritis, structural and functional abnormalities of proximal tubule resembling the Fanconi's syndrome and acute tubular necrosis. Although the pulmonary toxicities of silicon are relatively well documented as a cause of silicoproteinosis and lung fibrosis after acute and chronic exposure to free silica(SiO2), but is little known about the nephrotoxicity of this trace element. Clinical manifestations of silicon nephropathy are similar to other heavy metal nephropathy as proteinuria, hematuria, active urinary sediments and renal failure. Diagnosis of silicon nephropathy is based on distinct exposure history to silica, variable degree of renal dysfunction and characteristic histologic findings such as cytoplasmic vacuoles and dense membrane-enclosed cytoplasmic bodies which is resembling lysosomes in proximal tubular cells. A 26-year-old man with ingestion of silicon compound(SiO2-NaOCO3) developed acute renal failure due to acute tubular necrosis. And he was recovered with conservative management to acute renal failure. So we report this case with a brief review of literature.

Keyword

Silicon; Acute renal failure; Lysosomes

MeSH Terms

Acute Kidney Injury*
Adult
Cytoplasm
Diagnosis
Eating*
Fibrosis
Glomerulonephritis
Hematuria
Humans
Lung
Lysosomes
Necrosis
Nephritis, Interstitial
Nephrotic Syndrome
Proteinuria
Renal Insufficiency
Silicon Dioxide
Silicon*
Vacuoles
Silicon
Silicon Dioxide