Korean J Nephrol.  2010 Sep;29(5):662-666.

A Case of Hemolytic Uremic Syndrome Following Mitomycin C Treated with Long Intensive Plasmapheresis

• Shin DH
• Lee MJ
• Park HS
• Kim JK
• Park JT
• Chang TI
• Yoo TH
• Kang SW
• Choi KH

Abstract

HUS (Hemolytic Uremic Syndrome) is characterized by acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. In classical HUS, hemorrhagic diarrhea precedes. It is frequently associated with E. Coli O157:H7. Less frequently, HUS may also develop after various treatments such as mitomycin C, cyclosporine, quinine, and ticlopidine. Plasmapheresis is effective in most of classical HUS, which induces a complete remission in most patients with classical HUS. However, this treatment is ineffective in HUS associated with mitomycin C. Although Plasmapheresis is effective on hematologic abnormality in this atypical HUS, chronic renal insufficiency frequently persists as a sequella in HUS associated with mitomycin C. We here report on one patient who developed HUS following mitomycin C therapy due to cervix cancer. The patient was treated with intensive and prolonged plasmapheresis. There was a complete hematologic improvement and steady improvement in renal function.

Keyword

Hemolytic-Uremic syndrome; Mitomycin; Plasmapheresis

MeSH Terms

Acute Kidney Injury
Anemia, Hemolytic
Cyclosporine
Diarrhea
Hemolytic-Uremic Syndrome
Humans
Mitomycin
Plasmapheresis
Quinine
Renal Insufficiency, Chronic
Thrombocytopenia
Ticlopidine
Uterine Cervical Neoplasms
Cyclosporine
Mitomycin
Quinine
Ticlopidine