Korean J Nephrol.
2010 Sep;29(5):638-643.
A Case of AA Amyloidosis Treated with Infliximab
- Affiliations
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- 1Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. eawha@medimail.co.kr
- 2Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
Abstract
- AA amyloidosis is one of the most significant complications of rheumatoid arthritis characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. This disorder displays variable clinical symptoms depending upon the involved organ and a diagnosis is rendered through a biopsy of the affected organ, followed by staining using Congo-red which reveals an apple-green birefringence. Fundamental disease control is critical in the treatment of AA amyloidosis. Anti-tumor necrosis factor alpha (anti TNF-alpha) agents are promising in inducing clinical remission by suppressing systemic inflammation in AA amyloidosis. We report a case of AA amyloidosis in a 71 year old woman with rheumatoid arthritis that responded well to infliximab therapy.
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