Korean J Hematol.  2011 Sep;46(3):200-202. 10.5045/kjh.2011.46.3.200.

Clinical significance of anti-mitochondrial antibodies in a patient with chronic graft-versus-host disease following hematopoietic stem cell transplantation

• Lee DH
• Huh SJ
• Yoon HH
• Lee SW
• Kim KH
• Kim SH

• KMID: 2252005
• DOI: http://doi.org/10.5045/kjh.2011.46.3.200

Abstract

Recent studies indicate that patients with chronic graft-versus-host disease (GVHD) are not expected to show positivity for anti-mitochondrial antibody (AMA), which is a specific disease marker for primary biliary cirrhosis (PBC). A differential diagnosis between PBC and hepatic involvement of GVHD based on clinical manifestations and pathologic study is difficult because both diseases show similar results. Therefore, the presence of AMA may be important for distinguishing each disease. Here, we report a case of hepatic involvement of chronic GVHD with positive AMA, in which the pathologic findings and initial presentation of clinical findings were compatible with both PBC and chronic GVHD.

Keyword

Autoantibody; Anti-mitochondrial antibody; Chronic graft-versus-host disease; Hematopoietic stem cell transplantation

MeSH Terms

Antibodies
Diagnosis, Differential
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Humans
Liver Cirrhosis, Biliary
Antibodies

Figure

• 

  Fig. 1 Liver biopsy reveals mild biliary epithelial damage of portal tract, lymphocytic infiltraion and mild peacemeal necrosis.

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