Korean J Dermatol.
2001 Feb;39(2):209-211.
A Case of Localized Scleroderma Improved with Systemic PUVA Therapy
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- 1Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea.
Abstract
- The pathogenesis of scleroderma has not been completely delineated, but it is suggested that increased collagen expression in fibroblast from sclerotic skin lesions may be an important factor contributing to collagen accumulation. PUVA therapy has been reported to be effective in the treatment of localized scleroderma. Its mechanism of action appears to be the stimulation of collagenase production by dermal fibroblasts. We report a case of localized scleroderma improved with systemic PUVA therapy.
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