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The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma

Yu Y, Shen L, Xie X, Zhao J, Jiang M

BACKGROUND: Scleroderma is a multisystem disease in which tissue fibrosis is caused by inflammation and vascular damage. The mortality of scleroderma has remained high due to a lack of effective...
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A Case of Overlap Syndrome of Systemic Sclerosis and Cryoglobulinemic Vasculitis With Central Nervous System Involvement

Jung Y, Emily Lee E, Yeo J, Kim MH, Choi SR, Song YW

Mixed cryoglobulinemic vasculitis (CV) is occasionally caused by autoimmune diseases including systemic sclerosis. Multiorgan involvement such as skin, kidney, and peripheral nerve involvement is common in mixed CV. However, central...
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Treatment of Linear Morphea (en Coup de Sabre) with Micronized Acellular Dermal Matrix Filler: A Case Report

Kim J, Kim J, Lee YI, Lee JH

En coup de sabre variant of linear morphea (LM) is a rare sclerotic skin disorder characterized by disfiguring linear depression of the frontal or frontoparietal forehead. Current attempts for cosmetic...
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Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model

Jin X, Hou J, Zheng K, Wei D, Zhang A, Wang S, Mei H, Li C, Cheng L, Sun X

Background and Objectives: Systemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory disease. In this study, preventive effect of single systemic...
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Fabrication of removable partial denture on scleroderma patient using 3-dimensional intraoral scanner

Kim UG, Han JS, Yoon HI, Yeo ISL

A three-dimensional (3D) intraoral scanner, which is one of the major developments in digital dentistry, is widely used in fixed prosthodontics. The application of intraoral scanner is now increasing in...
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Esophageal Involvement and Determinants of Perception of Esophageal Symptoms Among South Koreans With Systemic Sclerosis

Lee JS, Kim HS, Moon JR, Ryu T, Hong SJ, Cho YS, Park J, Lee TH

  • KMID: 2507113
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):477-485.
  • doi: 10.5056/jnm19148
Background/Aims Our study aims to characterize esophageal motor function; evaluate the relationships among esophagogastroduodenoscopy (EGD), high-resolution manometry (HRM), and 24-hour esophageal multichannel intraluminal impedance monitoring combined with pHmetry (MII-pH); and elucidate...
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Localized Scleroderma with Concomitant Port-wine Stain

Kang MJ, Won YY, Lew BL, Sim WY

  • KMID: 2502309
  • Korean J Dermatol.
  • 2020 Feb;58(2):147-148.
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Diffuse Systemic Sclerosis in a Patient with Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome: A Case Report

Han HS, Ahn GR, Kim HJ, Park KY, Li K, Seo SJ

Systemic sclerosis (SSc) is a chronic systemic disease of unknown etiology characterized by vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other internal organs. Although its...
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Diagnosis of Systemic Scleroderma in a Patient with Leg Ulcer

Ju GS, Son KM, Choi WY, Cheon JS

Systemic scleroderma is an autoimmune disease that affects connective tissue in internal organs and the skin with thickening and fibrosis. When afflicting internal organs, the disease leads to reduced quality...
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The Significance of NOTCH Pathway in the Development of Fibrosis in Systemic Sclerosis

Zmorzyński S, Styk W, Filip AA, Krasowska

Systemic sclerosis (SSc) is an autoimmune disorder characterized by the fibrosis of skin, heart, lung, and kidney as well. Excessive activation of fibroblasts is associated with higher expression of Notch1...
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A Rare Case of Bilateral Frontal Linear Scleroderma (En Coup de Sabre)

Hong JR, Lee JS, Lee YW, Choe YB, Ahn KJ

  • KMID: 2454381
  • Korean J Dermatol.
  • 2019 Jul;57(6):346-347.
No abstract available.
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A surgical approach to linear scleroderma using Medpor and dermal fat graft

Kim KT, Sun H, Chung EH

Linear scleroderma en coup de sabre (LScs) is a variant of localized scleroderma. This disease typically occurs in patients in their 20s or younger individuals and predominantly occurs in the...
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Endoscopic Features of Upper Gastrointestinal Tract in Patients with Systemic Sclerosis Compared to the Healthy Control

Park JW, Kim J, Kang EA, Kim MJ, Kim JS, Lee EB

OBJECTIVE: To characterize the endoscopic features of upper gastrointestinal tract in patients with systemic sclerosis (SSc) compared with those in the healthy controls. METHODS: Data on esophagogastroduodenoscopy (EGD) in 180 patients...
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Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

Lee JS, Park HS, Cho S, Yoon HS

Although a few reports have noted the concurrent presentation of morphea and vitiligo at distinctly separate sites in the same patient, it is extremely rare that these two conditions occur...
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Systemic Sclerosis and Pleural Effusion in a Patient with Ankylosing Spondylitis

Koo BS, Song Y, Lee S, Kim TH, Jun JB

Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by endothelial and fibroblast dysfunction, resulting in progressive fibrosis of the skin and internal organs. Ankylosing spondylitis (AS) is an arthritic...
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Surgical Management of Localized Scleroderma

Lee JH, Lim SY, Lee JH, Ahn HC

BACKGROUND: Localized scleroderma is characterized by a thickening of the skin from excessive collagen deposits. It is not a fatal disease, but quality of life can be adversely affected due...
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Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist's point of view

Koo SM, Uh ST

Interstitial lung disease (ILD) occurs in 15% of patients with collagen vascular disease (CVD), referred to as connective tissue disease (CTD). Despite advances in management strategies, ILD continues to be...
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Systemic Sclerosis Associated with Non-small Cell Lung Cancer and Papillary Thyroid Cancer: Case Report and Literature Review

Kim HJ, Kim JJ, Park HJ, Kim YT

We report the case of a 52-year-old patient with rheumatic vascular disease (systemic sclerosis), non-small cell lung cancer, and papillary thyroid cancer. Malignant tumors have been described in 3-11% of...
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Long-term Outcomes of Autologous Peripheral Blood Stem Cell Transplantation for Refractory Rheumatic Diseases

Lee S, Bae SC, Jun JB, Choi CB

OBJECTIVE: We investigated the long-term outcomes of autologous peripheral blood stem cell transplantation (PBSCT) to treat refractory rheumatic diseases. METHODS: Patients who underwent PBSCT for refractory rheumatic diseases at our institution...
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Periostin in Mature Stage Localized Scleroderma

Kim MW, Park JT, Kim JH, Koh SJ, Yoon HS, Cho S, Park HS

BACKGROUND: Periostin is a novel matricellular protein expressed in many tissues, including bone, periodontal ligament, and skin. Although its expression is prominent in various fibrotic conditions, studies of periostin in...
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