J Breast Cancer.  2009 Sep;12(3):215-218. 10.4048/jbc.2009.12.3.215.

Metastasis of Non-Small Cell Lung Cancer to Ipsilateral Breast: A Case Report

• Kim JH
• Yom CK
• Kim YE
• Park YL
• Bae WG
• Oh TY
• Sohn JH

• KMID: 2242014
• DOI: http://doi.org/10.4048/jbc.2009.12.3.215

Abstract

Breast tissue is an unusual site for metastatic disease, particularly for non-small cell lung cancer (NSCLC). Aside from contralateral breast cancer, the most common tumors metastasizing to the breast are malignant melanoma and hematopoietic malignances. We recently experienced a case of a 49-year-old female patient with solitary metastasis of NSCLC to ipsilateral breast tissue. She was diagnosed as NSCLC of left lung and underwent left upper lobectomy in 2001. She was then treated with etoposide/cisplatin chemotherapy and radiation therapy. After 35 months, she was referred to our breast clinic because of a nodular opacity in the left breast revealed by screening breast ultrasound, which proved to be of pulmonary origin. She was treated by wide excision and with docetaxel/cisplatin chemotherapy. However, 37 months after breast surgery, a metastatic lesion developed in the same breast and she received modified radical mastectomy. We report this case with a review of the literature.

Keyword

Breast; Lung neoplasms; Neoplasm metastasis

MeSH Terms

Breast
Breast Neoplasms
Carcinoma, Non-Small-Cell Lung
Female
Humans
Lung
Lung Neoplasms
Mass Screening
Mastectomy, Modified Radical
Melanoma
Middle Aged
Neoplasm Metastasis

Figure

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  Figure 1 Breast sonography. (A) A 1.2 cm sized mass is noted in the 12 o'clock direction in the left breast. (B) A 0.8 cm sized oval shape mass is noted in the 1 o'clock direction in the left pectoralis muscle.

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  Figure 2 Pathologic finding. Left breast mass shows metastatic adenocarcnima (H&E stain, ×400).

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  Figure 3 Whole body PET-CT. The PET scan showed solitary metastatic lesion in the left breast (red arrow) without other systemic metastasis.

Reference

1. Toombs BD, Kalisher L. Metastatic disease to the breast: clinical, pathologic, and radiographic features. AJR Am J Roentgenol. 1977. 129:673–676.

2. Bohman LG, Bassett LW, Gold RH, Voet R. Breast metastases from extramammary malignancies. Radiology. 1982. 144:309–312.

3. McCrea ES, Johnston C, Haney PJ. Metastases to the breast. AJR Am J Roentgenol. 1983. 141:685–690.

4. Georgiannos SN, Chin J, Goode AW, Sheaff M. Secondary neoplasms of the breast. Cancer. 2001. 92:2259–2266.

5. Noguera JJ, Martínez-Miravete P, Idoate F, Diaz L, Pina L, Zornoza G, et al. Metastases to the breast: a review of 33 cases. Australas Radiol. 2007. 51:133–138.

6. Williams SA, Ehlers RA 2nd, Hunt KK, Yi M, Kuerer HM, Singletary SE, et al. Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival. Cancer. 2007. 110:731–737.

7. Vaughan A, Dietz JR, Moley JF, Debenedetti MK, Aft RL, Gillanders WE, et al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007. 5:74.

8. Sadikot RT, Renwick DS, DaCosta P, Chalmers AG, Pearson SB. Breast metastasis from non-small cell lung cancer. South Med J. 1997. 90:1063–1064.

9. Gómez-Caro A, Piñero A, Roca MJ, Torres J, Ferri B, Galindo PJ, et al. Surgical treatment of solitary metastasis in the male breast from non-small cell lung cancer. Breast J. 2006. 12:366–367.

10. Ucar N, Kurt OK, Alpar S, Orsel O, Demirag F, Kurt B. Breast metastasis in a male patient with nonsmall cell lung carcinoma. South Med J. 2007. 100:850–851.

11. Kim KS, Zang DY, Kim HJ, Ahn JS, Yoo JY, Hong KW, et al. A case of metastatic breast cancer from non-small cell lung cancer. Korean J Med. 2005. 69:S835–S839.

12. Luketich JD, Martini N, Ginsberg RJ, Rigberg D, Burt ME. Successful treatment of solitary extracranial metastases from non-small cell lung cancer. Ann Thorac Surg. 1995. 60:1609–1611.

13. Ambrogi V, Tonini G, Mineo TC. Prolonged survival after extracranial metastasectomy from synchronous resectable lung cancer. Ann Surg Oncol. 2001. 8:663–666.

14. Kim SH, Cha ES, Park JM, Kim HH, Kim JY, Park YH, et al. Radiologic findings of metastatic tumors to the breast. Korean J Radiol Soc. 1999. 41:601–606.

15. Yeh CN, Lin CH, Chen MF. Clinical and ultrasonographic characteristics of breast metastases from extramammary malignancies. Am J Surg. 2004. 70:287–290.