Korean J Hepatol.  1996 Mar;2(1):77-81.

A Case of Hypothyroidism Induced by Alpha-Interferon Therapy for Chronic Hepatitis B

Abstract

Thyroid dysfunction has heen reported as a side effect of alpha-interferon(IFN) therapy. The incidence of thyroid disorders was 1.2-12%' duripg 1FN therapy for chronic active hepatitis. We experienced a case of hypothyroidism developed after IFN therapy in a 48 year-old man with chronic hepatitis B. Baseline thyroid function before IFN therapy was normal and thyroid auioantibodies were also negative. High tiers ol' antimicrosomal antibody and anti-thyroglobulin antibody appeared and severe hypothyroidism followed at 6 months after starting the IFN therapy.

Keyword

Chronic hepatitis B; Alpha-interferon; Hypothyroidism

MeSH Terms

Hepatitis B, Chronic*
Hepatitis, Chronic*
Humans
Hypothyroidism*
Incidence
Interferon-alpha*
Middle Aged
Thyroid Gland
Interferon-alpha
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