Korean J Gastroenterol.
2000 Apr;35(4):529-533.
A Case of Small Cell Neuroendocrine Carcinoma in the Ampulla of Vater
Abstract
- Neuroendocrine neoplasms of the duodenum constitute 5% of all gastrointestinal carcinoids, but primary ampullary neuroendocrine tumors are very rare. Carcinoid tumors have been described as the most common primary ampullary neuroendocrine tumor. We experienced a 54-year-old man with small cell neuroendocrine carcinoma arising in the ampulla of Vater. Abdominal CT scan revealed dilated common bile duct and enhancing mass at the ampulla of Vater. Duodenoscopic findings showed a huge protruding mass with ulcerative orifice at the ampulla of Vater. Microscopic examination of the tumor revealed small monotonous anaplastic cells. The tumor cells were characterized with hyperchromatic nuclei and high nuclear to cytoplasmic ratio, frequent mitoses. Immunohistochemical staining was strongly positive for neuron specific enolase. We report this case with a review of literatures.
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