Korean J Dermatol.
1995 Dec;33(6):1129-1133.
Wegener' s Granulomatosis
Abstract
- Wegener's granulomatosis is a systemic necrotizing vasculitis of unknown cause. The disease is characterized by the involvement of the upper airway, the lung, and the kidney. Skin lesions are frequent and the most common lesion is purpura distributed on the limbs and trunk. A 34-year-old female showed recurrent purpuric macules on the both lower extremities and buttocks. The patient. showed nasal septal perforation with saddle nose deformity and C-ANCA positivity. Histopathologic findings of purpuric lesion revealed the features of necrotizing vasculitis. The histologic specimen from the nasal cavity showed chronic inflammation with granuloma formation and kidney showed focal necrotizing glomerulonephritis. Therefore, we treated the patient with prednisolone and cyclophosphamide having diagnosed Wegener's granulomatosis.
MeSH Terms
-
Adult
Antibodies, Antineutrophil Cytoplasmic
Buttocks
Congenital Abnormalities
Cyclophosphamide
Extremities
Female
Glomerulonephritis
Granuloma
Humans
Inflammation
Kidney
Lower Extremity
Lung
Nasal Cavity
Nasal Septal Perforation
Nose
Prednisolone
Purpura
Skin
Vasculitis
Wegener Granulomatosis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Prednisolone
