Regulation of the Collagen Gene Expression

Lee, Kyu Suk

Abstract

The genes that codify the subunits of the fibril-forming collagen constitute an evolutionarily related group within the collagen multigene family, Deposition of fibrillar molecules in the extrcellular matrix of several tissues influences a number of cellular activities such as adhesion, proliferation, and migration. In the developing and adult organisms, temporal and spatial expression of collasgen genes is modulated by a variety of cytokines and hormones, Likewise, transcription of collagen genes in tissue cultures can be greatly affected by the action of these substances and by chemical or viral transformation as well. Cytokine-mediated increase of collagen deposition on response to environmental stimuli is also the major histopathological feature of clinically distinct that similarly lead to overt firrotic processes. It is my heartily with to elucidate the mechanisms that regulate tissue specific expression of the human collagen genes a prerequisite for understanding the pathophysiology of diseased processes. Involving collagen metabolism, such as scleroderma.