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Clinical Characteristics of Psoriasis for Initiation of Biologic Therapy: A Cluster Analysis

Kim YH, Kim SI, Park B, Lee ES

Background: Psoriasis is a complex and heterogeneous disease that widely affects a patient’s life. Biological therapy is usually prescribed in patients with severe psoriasis that do not respond to conventional...
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Real-World Outcomes of Adalimumab Treatment for Moderate and Severe Psoriasis in Korean Patients (RAPSODI Study)

Kim DH, Son SW, Jeong KH, Ahn J, Lee ES, Kim IH, Lee UH, Park HJ, Ko JY, Kim BS, Kim JJ, Rashid J, Kim KJ

Background: Psoriasis imposes a significant treatment burden on patients, particularly impacting well-being and quality of life (QoL). The psychosocial impact of psoriasis treatments remains unexplored in most patient populations. Objective: To...
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Comparison of Risk Allele Frequencies of Psoriasis-Associated Single-Nucleotide Polymorphisms in Different Population Groups

Lee D, Koo T, Park J, Shin HT

Background: The prevalence of psoriasis differs by population, and it appears to be more common among Europeans than in East Asians. Recent genome-wide association studies (GWAS) have identified alleles that...
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Which Areas Are Still Left in Biologics Responsive Korean Patients with Moderate to Severe Plaque Psoriasis

Won SH, Shin BS, Bae KN, Son JH, Shin K, Kim HS, Ko HC, Kim MB, Kim BS

Background: Psoriasis localized to certain body areas, such as the scalp, nails, palms, soles, intertriginous regions, and genital regions, is reportedly difficult to treat. Objective: To investigate the biologics-resistant areas in...
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BNT162b2 (Pfizer) mRNA Covid-19 Vaccine Induced De Novo Generalized Pustular Psoriasis

Kim C, Kim K, Jung KE

  • KMID: 2539344
  • Korean J Dermatol.
  • 2023 Jan;61(1):71-73.
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A Case of Rebound Phenomenon after Cessation of Cyclosporine for Guselkumab Therapy in Psoriasis

Park SH, Jung SY

  • KMID: 2538565
  • Korean J Dermatol.
  • 2022 Dec;60(10):679-682.
Cyclosporine is one of the main therapeutic agents for psoriasis. It is known that psoriasis relapses 2∼3 months after discontinuation of cyclosporine, and exacerbation due to abrupt discontinuation of cyclosporine...
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Effect of Activating Transcription Factor 3 on Inflammatory Response and Differentiation of Keratinocytes

Kim K, Kim D, Shin JM, Hong D, Jung KE, Seo YJ, Lee Y, Kim CD

  • KMID: 2538560
  • Korean J Dermatol.
  • 2022 Dec;60(10):640-646.
Background: Pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune responses. Genetic background is one of the most important factors in disease pathogenesis. However, psoriasis-associated genes have not...
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Latent Tuberculosis Infection in Adult Patients with Severe Psoriasis Treated with Biologics at a Single Medical Center

Choi KH, Eun DH, Lee JY

  • KMID: 2538559
  • Korean J Dermatol.
  • 2022 Dec;60(10):631-639.
Background: Biologics have been increasingly used in the treatment of severe psoriasis. However, evidence regarding the results of tuberculosis (TB) screening and risk of latent tuberculosis infection (LTBI) during treatment...
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Low-level laser therapy in immune-mediated skin disease: a narrative review

Seok J, Koh YG, Kim BJ

Low-level laser therapy (LLLT) is now widely used in dermatology due to the relatively low risk of adverse events. LLLT can modulate mito­chondria levels and affect various cell types, such...
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A Case of Multiple Hyperkeratotic Seborrheic Keratosis in Psoriasis Lesion after Phototherapy

Kim JS, Lee JS, Koo DW

  • KMID: 2536325
  • Korean J Dermatol.
  • 2022 Nov;60(9):618-630.
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Eczematous Vesicular Rruption and Exacerbation of Chronic Spontaneous Urticaria Associated with Secukinumab

Choi SM, Lew BL, Sim WY, Kwon SH

  • KMID: 2536323
  • Korean J Dermatol.
  • 2022 Nov;60(9):611-614.
The pathogenesis of chronic spontaneous urticaria (CSU) is complex. Though the involvement of functional autoantibodies and imbalance of T helper (Th) cell subsets have been reported, the exact mechanism remains...
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A Case of Generalized Granuloma Annulare Development in a Psoriasis Patient Treated with Interleukin-12/23 Blockers

Kim J, Jang B, Kim Y, Won SH, Bae KN, Lee J, Shin K, Kim H, Ko H, Kim MB, Kim B

  • KMID: 2536322
  • Korean J Dermatol.
  • 2022 Nov;60(9):606-610.
Granuloma annulare is a relatively common inflammatory skin disease. The etiology is unknown; however, drugs have been considered as one of the predisposing conditions, and a few cases of granuloma...
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Expression of Antimicrobial Peptides in Psoriasiform Mouse Models

Kim SE, Lee SE, Kim SC, Kim JH

  • KMID: 2536318
  • Korean J Dermatol.
  • 2022 Nov;60(9):585-592.
Background: Psoriasis is a chronic inflammatory skin disease. Despite the current focus on T cells in the pathogenesis of psoriasis, keratinocytes within the psoriatic epidermis are also abnormal in many...
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Clinical Efficacy and Safety of Guselkumab in the Treatment of Moderate-to-Severe Psoriasis in Korea

Shin JO, Bae KN, Son JH, Shin K, Kim H, Ko H, Kim MB, Kim B

  • KMID: 2536315
  • Korean J Dermatol.
  • 2022 Nov;60(9):559-565.
Background: Guselkumab, a human immunoglobulin-G1λ monoclonal antibody, selectively blocks the interleukin-23-mediated signaling pathway. It has emerged as a promising treatment option for moderate-to-severe psoriasis. However, no studies have reported real-world...
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Available Alternative Biologics and Disease Groups Influence Biologic Drug Survival in Patients with Psoriasis and Psoriatic Arthritis

Oh S, Choi S, Yoon HS

Background: Factors other than efficacy and safety could influence the survival of biologics in patients with psoriasis. Little is known about whether different disease groups affect drug survival of biologics...
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Negative Correlation between CD163 Expression and Psoriasis Severity

Seo BH, Kim JS, Cha DR, Kim JH, Choi YS, Cha HJ, Suh HS

  • KMID: 2534011
  • Korean J Dermatol.
  • 2022 Sep;60(8):499-504.
Background: Psoriasis is a chronic inflammatory skin disease, wherein macrophages play a key role. An imbalance in transition from the classical activation (M1) to alternative activation (M2) phenotype in macrophages...
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Analysis of the Switching Patterns of Biologics and Their Efficacy after Switching in Moderate-to-Severe Psoriasis Patients

Lee SM, Ko BC, Ahn SW, Uh JA, Seol JE, Kim H, Lee SK, Kim MS, Lee UH, Park SH, Jung SY, Park HJ

  • KMID: 2532844
  • Korean J Dermatol.
  • 2022 Aug;60(7):420-428.
Background: Biologics-experienced patients are more likely to show a lower response to biologics than that of biologic-naïve patients. However, no consensus on switching biologics exists. Objective: We aimed to investigate the...
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Alteration of Th1 and Th17 Inflammatory Cytokines in the Skin Lesions after Psoriasis Treatment

Park HJ, Chang HJ, Kim TG, Kwon MY, Lim CY, Ju HJ, Lee KH, Park CJ

  • KMID: 2532842
  • Korean J Dermatol.
  • 2022 Aug;60(7):409-413.
Background: Psoriasis is a T cell-mediated disorder. Appropriate treatment of psoriasis can result in a plethora of dynamic changes in the T cells and their cytokine production. Studies on the...
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Correlation of HLA-Cw6 Positivity with Clinical Characteristics and Treatment Efficacy in Korean Patients with Psoriasis

Kim SM, Lee H, Lee ES

Background: Psoriasis is a multifactorial, chronic immunological disease, in which a specific allele HLA-Cw6 is associated with various clinical manifestations. However, information regarding this genetic factor in Korean patients with...
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Quantification of Efflorescences in Pustular Psoriasis Using Deep Learning

Amruthalingam L, Buerzle O, Gottfrois P, Jimenez AG, Roth A, Koller T, Pouly M, Navarini AA

Objectives: Pustular psoriasis (PP) is one of the most severe and chronic skin conditions. Its treatment is difficult, and measurements of its severity are highly dependent on clinicians’ experience. Pustules...
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