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Histopathological and Immunohistochemical Differentiation between Psoriasis and Seborrheic Dermatitis of the Scalp: Based on Langerin and CD1a

Yoon JH, Park HR, Park EJ, Kim KJ, Kim KH

  • KMID: 2520802
  • Korean J Dermatol.
  • 2021 Sep;59(8):634-639.
Background: Psoriasis and seborrheic dermatitis are difficult to distinguish if the lesion is localized to the scalp. Objective: To validify the use of langerin and CD1a as markers of Langerhans cells...
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Psoriasis and Cardiovascular Disease: A Narrative Review

Martinez-Moreno A, Ocampo-Candiani J, Garza-Rodriguez V

Psoriasis is a chronic, autoimmune, and inflammatory disease that affects 2% of the world’s population. In recent years, it has been demonstrated that psoriasis confers a 25% increase in relative...
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Potential Role of Cytosolic RNA Sensor MDA5 as an Inhibitor for Keratinocyte Differentiation in the Pathogenesis of Psoriasis

Hong DK, Choi MR, Hwang YL, Lee JK, Lee Y, Seo YJ, Kim S, Lee YH, Kim CD, Lee JH

Background: Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date,...
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Comparative Analysis of Treatment Outcomes Following Regular vs. Irregular Administration of Biologics in Patients with Psoriasis

Choi GW, Lim NJ, Shin JU, Lee HJ, Yoon MS, Kim DH

  • KMID: 2518986
  • Korean J Dermatol.
  • 2021 Jul;59(6):440-446.
Background: Patients with stable psoriasis showing clear/near-clear response can consider extending the dosing interval of biologics. However, few studies have reported the treatment outcomes following irregular dosing intervals of biologics...
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The Economic Burden of Psoriasis in Korea

Han B, Jeong KH, Kim TG, Kim KJ, Kim DH, Kim BS, Park KD, Park CJ, Park HJ, Bang CH, Shin BS, Youn SW, Youn JI, Lee JH, Jung KE, Choe YB, Jo Sj

  • KMID: 2517074
  • Korean J Dermatol.
  • 2021 Jun;59(5):321-331.
Background: Psoriasis is a chronic disease that can have accompanying comorbidities including arthritis, metabolic syndrome, and cardiovascular diseases. Patients with psoriasis tend to frequently visit medical institutions, and their economic...
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Association of Metabolic Comorbidities with Pediatric Psoriasis: A Systematic Review and Meta-Analysis

Cho SI, Kim YE, Jo SJ

Background: An evident relationship has been shown between psoriasis and metabolic comorbidities. However, the results in pediatric psoriasis vary from study to study, and no meta-analysis exists on the association...
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A Retrospective Analysis of the Factors Affecting the Treatment Outcomes of Cyclosporine in Patients with Psoriasis

Choi YG, Lee HJ, Choi YJ, Kim WS, Lee GY

  • KMID: 2516139
  • Korean J Dermatol.
  • 2021 May;59(4):266-276.
Background: Cyclosporine is an effective drug for the treatment of psoriasis. Nonetheless, little is known about the factors associated with its effectiveness. Objective: This study aimed to analyze the factors affecting...
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Aryl Hydrocarbon Receptor and Autophagy-Related Protein Microtubule-Associated Protein Light Chain 3 Expression in Psoriasis

Kim JE, Kim HR, Kang SY, Jung MJ, Heo NH, Lee HJ, Ryu A, Kim HO, Park CW, Chung BY

Background: The aryl hydrocarbon receptor (AHR) and autophagy are both important to maintain skin homeostasis.However, they are also involved in skin disorders. So far, their roles in psoriasis pathogenesis are...
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Toenail Psoriasis during Ustekinumab Therapy: Results and Limitations

Yang S, Kim BR, Kim M, Youn SW

Background: Nail psoriasis is a common clinically significant symptom of psoriasis. However, few studies have focused on the characteristics and course of toenail psoriasis. Objective: To investigate the treatment response...
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Clinical Characteristics of Psoriasis Patients with Elevated Total Serum Immunoglobulin E Levels: A Retrospective Single-Center Study

Seok SH, Im TB, Shin JU, Lee HJ, Yoon MS, Kim DH

  • KMID: 2513435
  • Korean J Dermatol.
  • 2021 Feb;59(2):94-99.
Background: Psoriasis is a chronic T17 cell-driven immune-mediated inflammatory disease. However, patients with psoriasis may have elevated total serum immunoglobulin E (IgE) levels, which is a hallmark of Th2 inflammation. In...
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Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Zhao X, Xing J, Li J, Hou R, Niu X, Liu R, Jiao J, Yang X, Li J, Liang J, Zhou L, Wang Q, Chang W, Yin G, Li X, Zhang K

Background and Objectives: Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an...
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Tumor Necrosis Factor-Alpha Inhibitor-Associated Psoriatic Alopecia in a Patient with Ulcerative Colitis:A Case Report and Review of the Literature

Jeong KM, Seo JY, Kim A, Baek YS, Song HJ, Jeon J

Paradoxical reactions in patients treated with tumor necrosis factor-alpha inhibitors (TNFis) have an estimated prevalence of 1.5% to 5%. Such reactions usually present as psoriasiform eruptions on the trunk and...
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Disseminated Tuberculosis in a Psoriasis Patient under Adalimumab Treatment despite the Chemoprophylaxis of Latent Tuberculosis: A Case Report

Oh JH, Ham SP, Park HJ

Recently, biologic therapy has become a major advance in the management of moderate-to-severe psoriasis. Although the overall safety profile of biologics is favorable, primary infection or reactivation of latent tuberculosis...
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A Large-Scale, Stratified Genetic Analysis of the Major Histocompatibility Complex Region in Early- and LateOnset Psoriasis in China

Zhou Y, Cai M, Sheng Y, Zhang X

Background: Psoriasis vulgaris is a chronic inflammatory skin disease which occur at any age. It can be clinically classified into two age-onset subtypes: early-onset psoriasis (EOP;<40 years) and late-onset psoriasis...
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Clinical Characteristics of Uveitis in Patients with Psoriasis in Korea: A Retrospective Multicenter Case Series

Lee Y, Oh BL, Yu HG, Youn SW, Woo SJ

Purpose: To describe the clinical characteristics and treatment outcomes of uveitis in patients with psoriasis in Korea. Methods: The medical records of 20 patients (27 eyes) with psoriatic uveitis in two...
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Clinical Features and Treatment Considerations When Switching Biologics in Korean Patients with Severe Psoriasis: A Retrospective Single-Centered Study

Kim TH, Kim DC, Lee ES

  • KMID: 2522540
  • Korean J Dermatol.
  • 2021 Nov;59(9):707-712.
Background: Since the advent of biologics, they have been an efficient treatment for severe psoriasis vulgaris. Psoriasis that is refractory to biologics is associated with factors, such as old age,...
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In Vitro Models Mimicking Immune Response in the Skin

Moon S, Kim DH, Shin JU

The skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been...
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The Role of Leptin in the Association between Obesity and Psoriasis

Hwang J, Yoo JA, Yoon H, Han T, Yoon J, An S, Cho JY, Lee J

Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is...
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Correlation of Serum Inflammatory Cytokine Levels with Clinical Characteristics Including Severity in Korean Patients with Psoriasis

Kim JC, Lee H, Cho SY, Park MJ, Lee ES

  • KMID: 2505559
  • Korean J Dermatol.
  • 2020 Aug;58(7):465-471.
Background: Psoriasis is a chronic relapsing inflammatory disease, with several cytokines related to its pathophysiology and clinical manifestations, such as disease activity, severity, and clinical subtype. However, there is limited...
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The Gut Microbiome: Human Health and Inflammatory Skin Diseases

Mann EA, Bae E, Kostyuchek D, Chung HJ, McGee JS

The human microbiome is a rich environment consisting ofbacteria, fungi and other commensal microorganisms of thegut, mucosa and skin. The functional role of the gut microbiomeincludes facilitation in metabolism of...
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