Korean J Clin Pathol.  2000 Dec;20(6):543-547.

A Case of Adult Neuroblastoma Involving Bone Marrow

• Kang MS
• Choi JW
• Chu YC
• Nahm CH
• Pai SH

Abstract

Neuroblastoma, which originates in the sympathetic division of the autonomic nervous system, is the most common extracranial solid malignancy in childhood but rarely occurs in adulthood. Only one case of neuroblastoma has been reported in Korean adult. Authors recently experienced a case of neuroblastoma originating from the retroperitoneal cavity with metastasis to the bone marrow and neck. A 29-year-old male was admitted at Inha University Hospital because of abdominal pain and back pain. The patient had a past history of chemotherapy for retroperitoneal tumor in a general hospital 4 years ago. In biochemical test, neuron specific enolase(NSE) was above 260 ng/mL and urine vanillylmandelic acid(VMA) was positive. Immunohistochemical stainings of bone marrow sections, showed positive reactions for NSE, chromogranin, and synaptophysin, however, revealed negative reactions for MIC2, vimentin, and mixed keratin. Pathologic examination showed the characteristic findings of neuroblastoma. We report this case with a review of literature.

Keyword

Neuroblastoma; Adult; bone marrow; Korean

MeSH Terms

Abdominal Pain
Adult*
Autonomic Nervous System
Back Pain
Bone Marrow*
Drug Therapy
Hospitals, General
Humans
Male
Neck
Neoplasm Metastasis
Neuroblastoma*
Neurons
Synaptophysin
Vimentin
Synaptophysin
Vimentin