Korean Circ J.  2010 Dec;40(12):680-683. 10.4070/kcj.2010.40.12.680.

A Case of Cogan's Syndrome With Angina

• Kim JS
• Park JB
• Joo JC
• Seol MD
• Yoon JW
• Park HK
• Won DJ
• Cho WH

• KMID: 2225169
• DOI: http://doi.org/10.4070/kcj.2010.40.12.680

Abstract

Cogan's syndrome is a rare systemic inflammatory disease and can be diagnosed on the basis of typical inner ear and ocular involvement with the presence of large vessel vasculitis. We report a case of Cogan's syndrome with stable angina resulting from coronary ostial stenosis caused by aortitis.

Keyword

Cogan syndrome; Angina pectoris; Aortitis

MeSH Terms

Angina Pectoris
Angina, Stable
Aortitis
Cogan Syndrome
Constriction, Pathologic
Ear, Inner
Glycosaminoglycans
Vasculitis
Glycosaminoglycans

Figure

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  Fig. 1 Exercise electrocardiogram. A: baseline electrocardiogram shows normal sinus rhythm with nonspecific ST-T changes. B: electrocardiogram during exercise at Bruce protocol stage 2 reveals significant ST segment depressions at lead II, III, aVF, V4, V5, V6.

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  Fig. 2 Transesophageal echocardiogram shows retracted tips of aortic cusps in systolic phase (A), moderate aortic regurgitation in diastolic phase (B), and increased wall thickening at the descending thoracic aorta (C). Arrow indicates thickened intima.

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  Fig. 3 Angiography shows ostial left main stenosis (A), ostial right coronary stenosis (B), and bilateral subclavian stenosis (C). A: right anterior oblique view. B: left anterior oblique view. C: anteroposterior view.

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  Fig. 4 Intravascular ultrasound shows increased intimal thickening at distal left main coronary (A) and negative remodeling with stenosis at ostial left main coronary artery (B).

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  Fig. 5 Angiography after successful stenting shows widened left main ostium.

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