Korean J Clin Microbiol.  2012 Mar;15(1):1-8. 10.5145/KJCM.2012.15.1.1.

Carbapenem-Resistant Acinetobacter baumannii

  • 1Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea. kscpjsh@yuhs.ac


Clinical isolates of Acinetobacter spp. in Korea exhibit higher antimicrobial resistance rates than in foreign countries and frequently show multi-drug resistance. Approximately 67% (272/405) of Acinetobacter baumannii isolates collected from 19 hospitals in Korea in 2008 exhibited intermediate susceptibility or resistance to imipenem and/or meropenem. The most important mechanisms in acquiring carbapenem resistance in A. baumannii in Korea are production of OXA-23 and overproduction of OXA-51, while that in non-baumannii Acinetobacter is the production of metallo-beta-lactamases. All the carbapenem-resistant A. baumannii isolates were identified as clonal complex 92 and belonged to worldwide clone 2.


Acinetobacter baumannii; Carbapenem; Worldwide clone 2

MeSH Terms

Acinetobacter baumannii
Clone Cells
Drug Resistance, Multiple


  • Fig. 1 Trend of antimicrobial resistance of Acinetobacter baumannii clinical isolates. Abbreviations: PIP, piperacillin; CAZ, ceftazidime; FEP, cefepime; AN, amikacin; SXT, trimethoprim-sulfamethoxazole; LFX, levofloxacin; IPM, imipenem.

  • Fig. 2 Acinetobacter spp. clinical isolate resistant to carbapenems in the world.

  • Fig. 3 Worldwide dissemination of carbapenemase in Acinetobacter spp.

  • Fig. 4 Distribution of variety clones in carbapenemase producing Acinetobacter baumannii.


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