Korean J Anat.  1999 Feb;32(1):17-24.

Changes of neuropeptides immunoreactivity according to dehydration in paraventricular nuclei

• Park IS
• Kim JT

Abstract

Dehydration induced an increase in plasma osmotic pressure that causes the release of the neurohypophysial hormone (Vasopresin, Oxytocin) which are synthesized in neurons of the paraventricular (PVN) and supra optic (SON) nuclei in the hypothalamus. On the other hand, PVN which plays an important role as an integration site for the neuroendocrine and autonomic nervous system neurons responded to osmotic stimulation. In this experiment, we studied that the change of several neuropeptidies (AVP: arginine vasopressin, CRF: cor-ticotrophin releasing factor, GAL: galanin, NT: neurotensin. NPY: neuropeptide Y) immunoreactivity in the PVN according to the dehydration. The body weight of the rats decreased during dehydration and various changes were detected in hypothalamic neuropeptidies immunoreactivity.Our results show that: 1. Dehydration significantly increased AVP, CRF and GAL immunoreactivity in the PVN. 2. Dehydration slowly decreased NT immunoreactivity in the PVN. 3. NPY immunoreactive cell bodys were appeared during dehydration which did not observed in PVN at normal group.

Keyword

paraventricular (PVN) nuclei; dehydration; neuropeptidie; immunocytochemistry

MeSH Terms

Animals
Arginine Vasopressin
Autonomic Nervous System
Body Weight
Dehydration*
Galanin
Hand
Hypothalamus
Immunohistochemistry
Neurons
Neuropeptides*
Neurotensin
Osmotic Pressure
Plasma
Rats
Arginine Vasopressin
Galanin
Neuropeptides
Neurotensin