Korean J Anat.
2007 Sep;40(3):203-210.
Screening of Interacting Proteins with PV.1 as Downstream Factors of BMP Signal
- Affiliations
-
- 1National Institute of Health, United States of America.
- 2Department of Anatomy, School of Medicine, Kyungpook National University, Taegu, South Korea. mjpark@knu.ac.kr
- 3Department of Oral Anatomy, School of Dentistry, Kyungpook National University, Taegu, South Korea.
Abstract
- Homeodomain transcription factors functioning downstream of BMP ventral pathway have been reported to share similar domain of roles in mesoderm patterning along the dorsal-ventral axis. To elucidate the differential role of PV.1 in the aspect of relationship between dorsal and ventral region, we tried to screen PV.1- interacting proteins. Twenty-four PV.1-interacting proteins were identified by yeast two-hybrid screening. Xvent-2 and Xclaudin-6 among these, went under domain study. The C-terminus of PV.1, more specifically 197-241 region was found to interact with Xclaudin-6. Meanwhile Xvent-2 has mild affinity to overall C-terminal region of PV.1. At the same time it was found that Xvent-2 homodimerizes and also binds to Xclaudin-6.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Zinc upregulates bone-specific transcription factor Runx2 expression via BMP-2 signaling and Smad-1 phosphorylation in osteoblasts
- Bone Morphogenetic Protein Signaling: Implications in Urology
- Temporal and Spatial Expression of Bone Morphogenetic Protein -2 and -4 mRNA in Distraction Osteogenesis and Fracture Healing
- The Analysis of Bone regenerative effect with carriers of bone morphogenetic protein in rat calvarial defects
- The Effects of Bone Morphogenetic Protein and Epidermal Growth Factor on the Periodontal Tissue Regeneration
