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Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system

Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z

Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most...
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Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney

Zhang J, Li K, Kong F, Sun C, Zhang D, Yu X, Wang X, Li X, Liu T, Shao G, Guan Y, Zhao S

BACKGROUND: Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once...
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Embryological Consideration of Dural AVFs in Relation to the Neural Crest and the Mesoderm

Tanaka M

Intracranial and spinal dural arteriovenous fistulas (DAVFs) are vascular pathologies of the dural membrane with arteriovenous shunts. They are abnormal communications between arteries and veins or dural venous sinuses that...
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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Characterization of Human Fetal Cartilage Progenitor Cells During Long-Term Expansion in a Xeno-Free Medium

Kim HR, Kim J, Park SR, Min BH, Choi BH

BACKGROUND: Stem cell therapy requires a serum-free and/or chemically-defined medium for commercialization, but it is difficult to find one that supports long-term expansion of cells without compromising their stemness, particularly...
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Induction of Rhesus Keratinocytes into Functional Ameloblasts by Mouse Embryonic Dental Mesenchyme

Ruan N, Lin C, Dong X, Hu X, Zhang Y

Fast progresses in stem cell-based tooth tissue engineering have been achieved in recent years in several animal models including the mouse, rat, dog, and pig. Moreover, various postnatal mesenchymal stem...
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The use of human mature cystic ovarian teratoma as a model to study the development of human lymphatics

Al-Jomard , Amarin Z

The angiogenic theory to the development of human lymphatics is not clear. The objective of this study was to investigate the development of human lymphatics. Semi-thin and thin paraffin sections...
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Unusual Contiguous Soft Tissue Spread of Advanced Malignant Mesothelioma Detected by FDG PET/CT

Zhang Y, Edwards J, Williams H, Hao Z, Khleif S, Pucar D

Malignant pleural mesothelioma (MPM) is a tumor of mesodermal origin that arises from the serosa of the pleura, peritoneum, pericardium or tunica vaginalis. MPM is well known to have a...
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Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation

Kim Y, Kim N, Park SW, Kim H, Park HJ, Han YM

Although microRNAs have emerged as key regulators in diverse cellular processes, the roles of microRNAs are poorly understood in human embryonic stem cells (hESCs) during differentiation into specialized cell types....
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A Case of Fibrous Mass Diagnosed as Spidle Cell Rhabdomyosarcoma in the Vocal Fold

Kim DY, Hwang JH, Park IS, Lim JY

Rhabdomyosarcoma is an uncommon type of soft tissue malignant neoplasm characterized by undifferentiated mesodermal tissue. Sarcomas account for approximately 1% of all laryngeal neoplasm and rhabdomyosarcomas are the rarest sarcoma...
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Induced Pluripotent Stem (iPS) Cells in Dentistry: A Review

Malhotra N

iPS cells are derived from somatic cells via transduction and expression of selective transcription factors. Both viral-integrating (like retroviral) and non-integrating (like, mRNA or protein-based) techniques are available for the...
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Immunomodulatory Function of Mesenchymal Stem Cells for Rheumatoid Arthritis

Kang MI, Park YB

Developments in our comprehension of the autoimmune and inflammation mechanisms in rheumatoid arthritis (RA) have produced targeted therapies that block aberrant immune cells and cytokine networks, and improved treatment of...
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The Role of Autonomous Wntless in Odontoblastic Differentiation of Mouse Dental Pulp Cells

Choi H, Kim TH, Ko SO, Cho ES

PURPOSE: Wnt signaling plays an essential role in the dental epithelium and mesenchyme during tooth morphogenesis. Deletion of the Wntless (Wls) gene in odontoblasts appears to reduce canonical Wnt activity,...
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Understanding of Human Embryo Development for Teratogen Counselling

Chun Y, Lee H

Human embryology is the study of development from a single cell to a baby in 9 months. Implantation occurs at the end of the first week of development. The second...
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A Wide Spectrum of Axial Mesodermal Dysplasia Complex With Rhombencephalic Anomaly: A Case Report

Kim KW, Seo JH, Ko MH, Won YH, Park SH

Axial mesodermal dysplasia complex (AMDC) arises in variable combinations of craniocaudal anomalies such as musculoskeletal deformities, neuroschisis, or rhombencephalic developmental disorders. To the best of our knowledge, the co-existence of...
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A Case of Klippel-Trenaunay Syndrome with Acute Submassive Pulmonary Thromboembolism Treated with Thrombolytic Therapy

Chu ST, Han YH, Koh JA, Kim SJ, Lee HC, Kim SE, Shin YC, Sir JJ, Choi SM, Joo SB

Klippel-Trenaunay syndrome is a rare congenital mesodermal abnormality characterized by varicose veins, cutaneous hemangiomas, soft tissue and bony hypertrophy of limb. Potential complications such as deep venous thrombosis and pulmonary...
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Tongue Growth during Prenatal Development in Korean Fetuses and Embryos

Hong SJ, Cha BG, Kim YS, Lee SK, Chi JG

BACKGROUND: Prenatal tongue development may affect oral-craniofacial structures, but this muscular organ has rarely been investigated. METHODS: In order to document the physiology of prenatal tongue growth, we histologically examined the...
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Nfic regulates tooth root patterning and growth

Kim TH, Bae CH, Yang S, Park JC, Cho ES

Molecular interactions between epithelium and mesenchyme are important for root formation. Nuclear factor I-C (Nfic) has been identified as a key regulator of root formation. However, the mechanisms of root...
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Two Cases of Rhabdomyomatous Mesenchymal Hamartoma

Kim JA, Park CJ, Lee KH

  • KMID: 1789614
  • Korean J Dermatol.
  • 2015 Mar;53(3):244-246.
Rhabdomyomatous mesenchymal hamartoma is a rare skin lesion composed of a haphazard arrangement of skeletal muscle, adipocytes, and collagen. Lesions usually present as a solitary sessile papule or nodule on...
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Unilateral noncystic renal dysplasia in a Sprague Dawley rat

Lee YH, Kim D, Park SH, Lee MJ, Kim MJ, Jang HS, Kang JS, Kang J

  • KMID: 1709211
  • J Biomed Res.
  • 2014 Jun;15(2):92-95.
Renal dysplasia is a developmental disorder of the renal parenchyma involving anomalous differentiation. It is characterized by persistent metanephric ducts surrounded by primitive mesenchyme, fetal or immature glomeruli, fetal or...
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