Korean Circ J.  2014 Sep;44(5):355-357. 10.4070/kcj.2014.44.5.355.

Prasugrel-Induced Hypersensitivity Skin Reaction

• Kim SH
• Park SD
• Baek YS
• Lee SY
• Shin SH
• Woo SI
• Kim DH
• Kwan J

• KMID: 2223877
• DOI: http://doi.org/10.4070/kcj.2014.44.5.355

Abstract

We report a case of hypersensitivity skin reaction to prasugrel. The patient exhibited a generalized skin rash after treatment with prasugrel, which was resolved after discontinuation of prasugrel and substitution to clopidogrel. Clopidogrel was successfully administered as an alternative to prasugrel without any signs of further hypersensitivity.

Keyword

Prasugrel; Clopidogrel; Thienopyridine; Hypersensitivity; Exanthema

MeSH Terms

Exanthema
Humans
Hypersensitivity*
Skin*
Prasugrel Hydrochloride

Figure

• 

  Fig. 1 Photographs of patient with prasugrel-induced hypersensitivity skin reaction. A: exanthema on both forearms and hands. (A) shows exanthema on both forearms and hands after 5 days of prasugrel exposure. B: exanthema on the anterior chest and abdominal wall. (B) shows exanthema on anterior chest and abdominal wall.

• 

  Fig. 2 Microscopic section of punch biopsy of abdominal wall. Microscopic sections demonstrating perivascular lymphocyte infiltration of dermis and epidermis compatible with a hypersensitivity skin reaction.

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