J Rhinol.  2003 Nov;10(1, 2):23-26.

Lack of Association between an Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Allergic Rhinitis in a Korean Population

• Lee JH
• Choi TW
• Yoon SW
• Kim JJ

Abstract

BACKGROUND AND OBJECTIVES: Angiotensin -converting enzyme (ACE) inactivates bradykinin, substance P, and neurokinin A, which are thought to play important roles in the pathogenesis of inflammatory diseases. An insertion/deletion (I/D) poly - morphism in the ACE gene was reported to be associated with atopy in a Czech population.
MATERIALS AND METHODS
Using the polymerase chain reaction, we investigated the frequencies of the genotypes and alleles of the ACE gene in 137 patients with allergic rhinitis and 498 healthy control subjects.
RESULTS
There was no difference in the frequencies of the genotypes in the controls and patients with allergic rhinitis (p>0.05). The D allele was more frequent in patients with allergic rhinitis, but the difference was not statistically significant (p>0.05).
CONCLUSION
Our results indicate that I/D polymorphism in the ACE gene is not related to susceptibility to allergic rhinitis in the Korean population.

Keyword

Allergic rhinitis ; Angiotensin -converting enzyme gene; Polymorphism; Korean population

MeSH Terms

Alleles
Angiotensins
Bradykinin
Genotype
Humans
Neurokinin A
Polymerase Chain Reaction
Rhinitis*
Substance P
Angiotensins
Bradykinin
Neurokinin A
Substance P