J Korean Ophthalmol Soc.  2013 Jul;54(7):1060-1065. 10.3341/jkos.2013.54.7.1060.

Central Corneal Thickness and Corneal Endothelial Cells in Pseudoexfoliation Syndrome

Affiliations
  • 1Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. hyuny@medimail.co.kr
  • 2Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
To evaluate the central corneal thickness (CCT) and corneal endothelial cell density (ENDO) in pseudoexfoliation syndrome.
METHODS
Medical records of patients who underwent a preoperative examination for cataract surgery and an examination for glaucoma were retrospectively reviewed. The present study included 44 patients (59 eyes) and age- and sex-matched controls. The total pseudoexfoliation patients divided into 2 groups, such as pseudoexfoliation syndrome (28 eyes) and pseudoexfoliative glaucoma (21 eyes) .The intraocular pressure (IOP), CCT, ENDO, corneal curvature (CC) and axial length (AL) were measured.
RESULTS
The total pseudoexfoliation group showed significantly higher IOP (p = 0.001), thinner CCT (p = 0.003) and lower ENDO (p = 0.037). The pseudoexfoliation syndrome group showed significantly thinner CCT (p = 0.010) and lower EDNO (p = 0.041), but no significant difference in IOP (p = 0.941). There was no significant difference in CCT (p = 0.060) and ENDO (p = 0.171) between the pseudoexfoliative glaucoma group and controls, but the pseudoexfolliative glaucoma group showed significantly higher IOP (p < 0.001).
CONCLUSIONS
The pseudoexfoliation group showed thinner CCT which should be taken into consideration when evaluating IOP with the applanation tonometer and diagnosing glaucoma, especially in pseudoexfoliation syndrome patients.

Keyword

Central corneal thickness; Corneal curvature; Corneal endothelial cell density; Pseudoexfoliation syndrome

MeSH Terms

Cataract
Endothelial Cells
Exfoliation Syndrome
Glaucoma
Humans
Intraocular Pressure
Medical Records
Retrospective Studies
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