J Korean Ophthalmol Soc.  2012 Jan;53(1):87-93. 10.3341/jkos.2012.53.1.87.

Comparison of Choroidal Thickness in Eyes with Central Serous Chorioretinopathy, Asymptomatic Fellow Eyes and Normal Eyes

• Cho JH
• Bae SH
• Han JR
• Nam WH
• Kim HK

• KMID: 2215249
• DOI: http://doi.org/10.3341/jkos.2012.53.1.87

Abstract

PURPOSE
To compare the choroidal thickness in central serous chorioretiopathy (CSC) patients and normal controls using spectral domain optical coherence tomography (SD-OCT).
METHODS
The authors compared the choroidal thickness in eyes with CSC, fellow eyes and in normal eyes. In addition, the authors attempted to determine any correlation between choroidal thickness and other factors such as age, height of serous retinal detachment, and spherical equivalent. Choroidal thickness was measured using a perpendicular line from the outer margin of the subfoveal retinal pigment epithelium to the inner surface of the sclera.
RESULTS
Twenty-five eyes of 25 CSC patients, 17 fellow eyes and 29 age-matched normal eyes were examined and categorized as group 1, group 2 and group 3, respectively. Subfoveal choroidal thickness was 370.64 +/- 58.06 microm in group 1, 301.85 +/- 47.83 microm in group 2, and 261.84 +/- 48.22 microm in group 3. The choroidal thickness in group 1 was significantly greater than those in group 2 and group 3, and the choroidal thickness in group 2 was significantly greater than that in group 3 (p = 0.001, p < 0.001, p = 0.004, respectively), where the choroidal thickness showed a negative correlation with age (p = 0.015).
CONCLUSIONS
The choroidal thickness was greater in eyes with CSC and in their fellow eyes compared to that in normal eyes. The results suggest that CSC may be caused by choroidal vascular hyperpermeability and increased hydrostatic pressure in the choroid.

Keyword

Central serous chorioretinopathy; Choroidal thickness; Spectral domain optical coherence tomography

MeSH Terms

Central Serous Chorioretinopathy
Choroid
Eye
Humans
Hydrostatic Pressure
Retinal Detachment
Retinal Pigment Epithelium
Tomography, Optical Coherence

Figure

• 

  Figure 1 Representative images of both eyes in 40-year-old female patient with central serous chorioretinopathy. The choroid is seen in cross-section image acquired by Cirrus HD-OCT high-definition single-line raster scan mode. Perpendicular line was drawn from the outer border of the retinal pigment epithelium to the inner border of the sclera using Cirrus HD-OCT software. Subfoveal choroidal thickness was measured. Choroidal thickness was 379 µm in an eye of central serous chorioretinopathy (A) and 264 µm in an asymptomatic fellow eye (B).

• 

  Figure 2 Scatter plot of subfoveal choroidal thickness and age. In eyes with central serous chorioretinopathy (left), the choroidal thickness did not correlate with patient age (Spearman's correlation test, r = 0.276, p = 0.182). In normal eyes (right), however, the choroidal thickness showed negative correlation with age (Spearman's correlation test, r = -0.449, p = 0.015).

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