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Long-term Follow-up Results of Patients with Welding-arc Maculopathy Assessed Using Spectral Domain Optical Coherence Tomography

Kim JH, Kim BJ, Kang TS, Cho HK, Nam KY, Yoo JM, Han YS

PURPOSE: We present four cases of welding arc maculopathy as observed using spectral-domain optical coherence tomography (SD-OCT). CASE SUMMARY: Four patients, who performed welding without wearing protective eye gear, presented to...
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Fundus Albipunctatus Diagnosed in a 9-year-old Female

Nam KY, Kim BJ, Kim JH, Kang TS, Cho HK, Chung IY, Park JM, Han YS

PURPOSE: We report a case of fundus albipunctatus discovered in a young patient. CASE SUMMARY: A 7.6-year-old female showed numerous small whitish-yellow flecks in the perimacular area and retinal periphery. Dark...
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Sjögren's Reticular Retinal Dystrophy

Noh H, Bae K, Kang SW

PURPOSE: To report a rare case of Sjögren's reticular retinal dystrophy. CASE SUMMARY: A 54-year-old male presented with blurred vision and metamorphopsia in both eyes since a few years prior to...
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Generation of Retinal Pigmented Epithelium-Like Cells from Pigmented Spheres Differentiated from Bone Marrow Stromal Cell-Derived Neurospheres

Kadkhodaeian HA, Tiraihi T, Ahmadieh H, Ziaei H, Daftarian , Taheri T

BACKGROUND: Retinal degeneration causes blindness, and cell replacement is a potential therapy. The purpose of this study is to formation of pigmented neurospheres in a simple medium, low-cost, high-performance manner...
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A Case of Unilateral Focal Pigmented Paravenous Retinochoroidal Atrophy

Park HS, Yang JY, Park HJ

PURPOSE: We report a case of unilateral, focal, pigmented paravenous retinochoroidal atrophy (PPRCA). CASE SUMMARY: A 46-year-old female visited our clinic in complaint of a vague problem with her right eye...
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Analysis of 25-Hydroxy Vitamin D in the Aqueous Humor of Age-related Macular Degeneration Patients

Song WS, Yoon WT, Kim YK, Park SP

PURPOSE: We examined aqueous humor levels of 25-hydroxyvitamin D (vitamin D) in patients with age-related macular degeneration to investigate possible relationships between aqueous humor vitamin D levels and clinical manifestations. METHODS: Patients...
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Pars Plana Vitrectomy for Cystoid Macular Edema in a Retinitis Pigmentosa Patient

Choi YJ, Shin MH, Han YS, Seo SW, Yoo JM, Chung IY

PURPOSE: To report the first case of cystoid macular edema in a retinitis pigmentosa patient with pars plana vitrectomy. CASE SUMMARY: A 43-year-old female visited our hospital with visual disturbances of...
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A Case of Central Serous Chorioretinopathy after Tadalafil Treatment

Yoon YS, Lee S, Woo JM, Min JK

PURPOSE: To describe a patient who presented with central serous chorioretinopathy after 2 months of tadalafil administration without any other underlying disease or medication. CASE SUMMARY: A 49-year-old male patient was...
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Effects of Internal Limiting Membrane Peeling in Combined Hamartoma of Retina and Retinal Pigment Epithelium

Park JH, Park JM

PURPOSE: To evaluate the effects of peeling the internal limiting membrane (ILM) of an epiretinal membrane (ERM) for surgical treatment of combined hamartoma of the retina and retinal pigment epithelium...
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Changes of the Individual Retinal Layer Thickness in Non-proliferative Diabetic Retinopathy in Type 2 Diabetes

Kim SY, Jeong IW, Yang YS, Choi CW

PURPOSE: To compare retinal layer thickness in non-proliferative diabetic retinopathy in type 2 diabetic patients as measured by optical coherence tomography. METHODS: A total of 108 eyes from 71 patients, between...
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Changes in Macular Retinal Layers and Peripapillary Nerve Fiber Layer Thickness after 577-nm Pattern Scanning Laser in Patients with Diabetic Retinopathy

Shin JS, Lee YH

PURPOSE: The aim of this study was to evaluate the changes in thickness of each macular retinal layer, the peripapillary retinal nerve fiber layer (RNFL), and central macular thickness (CMT)...
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Identification of the PROM1 Mutation p.R373C in a Korean Patient With Autosomal Dominant Stargardt-like Macular Dystrophy

Kim JM, Lee C, Lee GI, Kim NK, Ki CS, Park WY, Kim BJ, Kim SJ

Stargardt-like macular dystrophy 4 (STGD4) is a rare macular dystrophy characterized by bull's eye atrophy of the macula and the underlying retinal pigment epithelium. Patients with STGD4 show decreased central...
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Anatomical Characteristics of End-stage Exudative Age-related Macular Degeneration Refractory to Intravitreal Anti-vascular Endothelial Growth Factor Injection

Hong JG, Cho YW, Jang JH

PURPOSE: To analyze the anatomical characteristics on spectral-domain optical coherence tomography (SD-OCT) of patients who are legally blind (less than 20/1,000) due to end-stage exudative age-related macular degeneration (AMD) that...
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Change of Outer Retinal Thickness in Fellow Eyes of Patients with Unilateral Age-related Macular Degeneration

Jeong HK, Kim SS, Park HJ

PURPOSE: To compare the outer retinal thickness in normal fellow eyes of patients with unilateral age-related macular degeneration (AMD) and normal control eyes. METHODS: We retrospectively reviewed the medical records of...
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Distribution and Function of the Bestrophin-1 (Best1) Channel in the Brain

Oh SJ, Lee CJ

Bestrophin-1 (Best1) is a calcium-activated anion channel identified from retinal pigment epithelium where human mutations are associated with Best's macular degeneration. Best1 is known to be expressed in a variety...
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The Thickness of Each Retinal Layer and Visual Acuity after Vitrectomy in Idiopathic Epiretinal Membrane

Kim MH, Jeon CY, Baek SK, Chang YS, Lee YH

PURPOSE: In this study, we evaluated the thickness of each retinal layer using spectral-domain optical coherence tomography (OCT) and investigated the correlation between the thickness of each retinal layer and...
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Inhibition by miR-410 facilitates direct retinal pigment epithelium differentiation of umbilical cord blood-derived mesenchymal stem cells

Choi SW, Kim JJ, Seo MS, Park SB, Shin TH, Shin JH, Seo Y, Kim HS, Kang KS

Retinal pigment epithelium (RPE) is a major component of the eye. This highly specialized cell type facilitates maintenance of the visual system. Because RPE loss induces an irreversible visual impairment,...
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Generation of Retinal Progenitor Cells from Human Induced Pluripotent Stem Cell-Derived Spherical Neural Mass

Yun C, Oh J, Lee B, Lee JM, Ariunaa T, Huh K

Spherical neural mass (SNM) is a mass of neural precursors that have been used to generate neuronal cells with advantages of long-term passaging capability with high yield, easy storage, and...
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Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells

Hwang N, Kwon MY, Cha JB, Chung SW, Woo JM

PURPOSE: To investigate the production of long pentraxin 3 (PTX3) in response to tunicamycin-induced endoplasmic reticulum (ER) stress and its role in ER stress-associated cell death, PTX3 expression was evaluated...
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High Dose Intravitreal Bevacizumab for Refractory Pigment Epithelial Detachment in Age-related Macular Degeneration

Lee DK, Kim SH, You YS, Kwon OW

PURPOSE: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is the first choice of treatment for age-related macular degeneration. However, quite a few eyes treated using conventional dose anti-VEGF (CDAV) have persistent...
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