J Korean Ophthalmol Soc.  2009 Feb;50(2):290-293. 10.3341/jkos.2009.50.2.290.

A Case of Eyelid Schwannoma

• Lee KW
• Lee MJ
• Kim NJ
• Choung HK
• Khwarg SI

• KMID: 2212065
• DOI: http://doi.org/10.3341/jkos.2009.50.2.290

Abstract

PURPOSE: To report a rare case of solitary eyelid schwannoma.
CASE SUMMARY
A 60-year-old female visited our clinic with a small cyst-like mass of the left upper eyelid, which had developed 3 years earlier. A 3x3 mm-sized, nonpigmented, cyst-like mass was located in the lateral area of the left upper eyelid margin. We performed an excisional biopsy under local anesthesia. The tumor was well encapsulated, easily dissected, and could be completely removed. Histopathologic examination showed cellular areas of spindle cells with Verocay bodies forming palisades and less cellular myxoid areas. Immunohistochemical analysis for S-100 protein showed a strongly positive reaction. Based on the histopathologic features, a diagnosis of benign Schwannoma was made.
CONCLUSIONS
Schwannoma should be also considered in the differential diagnosis of a well-circumscribed mass lesion in the eyelid.

Keyword

Eyelid; Schwannoma

MeSH Terms

Anesthesia, Local
Biopsy
Diagnosis, Differential
Eyelids
Female
Humans
Middle Aged
Neurilemmoma
S100 Proteins
S100 Proteins

Figure

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  Figure 1. Clinical photographs of the left eye. A. On the first visit, photomicrograph shows a 3x3 mm-sized non-pigmented cyst-like mass on the lateral areas of the upper eyelid margin (black arrow). B. At 2 years after the first visit, no interval changes of the size and color of the mass (black arrow).

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  Figure 2. Light micrograph of excisional biopsy specimen. (A) Photomicrographs show well- encapsulated mass (hematoxylin-eosin, ×10). (B) There are cellular areas of spindle cells and less cellular myxoid areas (hematoxylin-eosin, ×100). (C) There are compact arrangements of spindle cells with Verocay bodies forming palisades, consistent with Antoni type A tissue. (hematoxylin-eosin stain, ×200). (D) The tumor cells show intense positive staining with S-100 protein (S-100, ×200).

Reference

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