J Pathol Transl Med.  2016 Mar;50(2):168-171. 10.4132/jptm.2015.08.26.

Primary Neurilemmoma of the Thyroid Gland Clinically Mimicking Malignant Thyroid Nodule

• Lee YS
• Kim JS
• Chung AM
• Park WC
• Kim TJ

• KMID: 2211386
• DOI: http://doi.org/10.4132/jptm.2015.08.26

Abstract

No abstract available.

MeSH Terms

Neurilemmoma*
Thyroid Gland*
Thyroid Nodule*

Figure

• 

  Fig. 1. Imaging, cytologic analysis, and gross examination of thyroidal mass. (A) Ultrasonography showing a lobulated, hypoechoic mass (arrow) in the subcapsular region of the right thyroid lobe. (B) Postcontrast computed tomography imaging revealing a hypodense right thyroidal mass (arrow) compressing the right tracheal wall. (C) Fine needle aspiration cytology with a loose cluster of bland-looking spindle cells. (D) The complete thyroidectomy specimen showing an encapsulated, gray, firm mass replacing the right upper lobe.

• 

  Fig. 2. Histologic and immunihistochemical analysis of the mass. (A) Low magnification view showing a spindle cell lesion (right) sharply demarcated from the adjacent normal thyroid tissue (left) by a thick fibrous capsule. (B) High magnification view revealing both cellular Antoni A areas (arrows) and loose paucicellular Antoni B areas (asterisks). (C) Tumor cells (asterisk) are positive and fibroblasts (arrowheads) are negative for S-100 protein on immunohistochemical staining. (D) Both tumor cells (asterisk) and fibroblasts (arrowheads) are positive for fibroblast growth factor receptor 1 on immunohistochemical staining.

• 

  Fig. 3. Electron microscopy displaying long, enveloping cytoplasmic processes outlined by layers of discrete basal lamina.

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