J Korean Pediatr Soc.  1993 Nov;36(11):1630-1634.

A case of carbamazepine-induced toxic epidermal necrolysis

• Na GC
• Kim KS
• Jung EG
• Moon KR
• Park SK
• Park YB

Abstract

Drug-induced toxic epidermal necrolysis (TEN) is a bullous erythematous disease that is characterized by the appearance of scaled lesions and large sheets of pilling on the skin. A caseof TEN occured in a 10 month old female patient. The characteristic skin lesions of TEN developed after oral administration of carbamazepine for a partial seizure. Thig case consists of prodrome of malaise, fever, anorexia, and conjunctivity followed by erythema & flaccid bullae formation. Diagnosis was confirmed by histologic findings. This patient was treated with a massive systemic corticosteroid, antibiotics, fluid and electrolytes, and topical measures. Authors experienced an extremely rare case of TEN dur to carbamazepine, So report it with a brief review of literature.

Keyword

Carbamazepine; Toxic Epidermal Necrolysis

MeSH Terms

Administration, Oral
Anorexia
Anti-Bacterial Agents
Carbamazepine
Diagnosis
Electrolytes
Erythema
Female
Fever
Humans
Infant
Seizures
Skin
Stevens-Johnson Syndrome*
Anti-Bacterial Agents
Carbamazepine
Electrolytes