J Korean Pediatr Soc.  2000 Feb;43(2):188-194.

Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants

• Jo HS
• Choi CW
• Lee YK
• Kim HS
• Park JD
• Huh J
• Kim BI
• Noh CI
• Choi JH

Abstract

PURPOSE: Cisapride, a prokinetic agent, is widely used in preterm infants with feeding intolerance or gastroesophageal reflux. Although cisapride is regarded as a safe drug, increased QTc interval or ventricular arrhythmia has been reported in adults and neonates. So we prospectively examined the effects of cisapride on the QTc interval and QT dispersion in preterm infants.
METHODS
QTc interval and QT dispersion were determined just before and 4.9+/-1.7days after the start of the cisapride treatment in 15 preterm infants with cisapride between April 1, 1998 and August 31, 1998.
RESULTS
Cisapride significantly increased QTc interval(P<0.05), and this had no correlation with birthweight or gestational age. Three(20%) of the 15 cases were found to have QTc interval above 0.450, but they were clinically asymptomatic. QT dispersion did not increase significantly.
CONCLUSION
Cisapride use in preterm infants is associated with an increase in QTc interval. High dose or longterm use of cisapride in preterm infants should be used cautiously, and when used, monitoring the QTc interval should be considered.

Keyword

Cisapride; QTc interval; QT dispersion; Preterm infants

MeSH Terms

Adult
Arrhythmias, Cardiac
Cisapride*
Gastroesophageal Reflux
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Prospective Studies
Cisapride