J Korean Pediatr Soc.
2002 Dec;45(12):1585-1590.
A Case of Rhizomelic Chondrodysplasia Punctata Type I
- Affiliations
-
- 1Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea. ysped@inha.ac.kr
- 2Seoul Clinical Laboratory, Seoul, Korea.
Abstract
- Rhizomelic chondrodysplasia punctata(RCDP) is a rare autosomal recessive disorder clinically characterized by symmetrical shortening of the proximal limbs, contractures of joints, a typical dysmorphic face, cataracts, and itchyosis. Patients with RCDP can be subdivided into three subgroups based on biochemical analysis and complementation studies. RCDP type I results from mutations in the PEX7 gene encoding the peroxisomal targeting signal type II(PST2) receptors and presents with both a defect in plasmalogen biosynthesis and phytanic acid oxidation. RCDP type II is deficient in the activity of dihydroxyacetonephosphate acyltransferase(DHAP-AT). RCDP type III is deficient in alkyl-dihydroxyacetonephosphate synthase(alkyl-DHAP). We report a case of RCDP type I which was confirmed with biochemical study, fibroblast culture, and gene study.
