J Korean Ophthalmol Soc.  1997 Sep;38(9):1553-1560.

Long-term Outcome of Graft Rejection after Penetrating Keratoplasty

• Kim MK
• Lee JH

Abstract

We retrospectively analyzed long-term outcome of graft rejection after penetrating keratoplasty in 128 eyes of 110 patients at Seoul National University Hospital, over 66 months period. The most common preoperative diagnosis of recipients was keratoconus, and aphakic bullous keratopathy, herpes simplex keratitis and corneal ulcer were in order. The results obtained are as follows : The rejection rate was 45.3% (58 eyes) in all of the graft, and it was 35.1% in keratoconus. Graft rejection developed in 52 eyes(92.1%) within 1 year and two eyes after 3 years, and a eyes at 5 years after graft. Graft rejection was reversed in 39.7% (23 eyes) of all graft rejection cases and 75%(15 eyes) in keratoconus. Best corrected visual acuity of 100/200 or better was achieved by 64.9%, and that of keratoconus was 82.5%. In univariate analysis of graft survival, peripheral anterior synechia, previous history of glaucoma, the presence of combined operation, technique of suture, corneal neovascularization showed high correlation with graft rejection however donor age, recipient age, re-keratoplasty and the size of donor corneal button didn`t show correlation with development of graft rejection. In multivariate analysis of graft survival, previous history of glaucoma, lens status and the presence of combined operation showed high correlation with graft rejection.

Keyword

Keratoplasty; Rejection; risk factor; Survival rate

MeSH Terms

Corneal Neovascularization
Corneal Transplantation
Corneal Ulcer
Diagnosis
Glaucoma
Graft Rejection*
Graft Survival
Humans
Keratitis, Herpetic
Keratoconus
Keratoplasty, Penetrating*
Multivariate Analysis
Retrospective Studies
Risk Factors
Seoul
Survival Rate
Sutures
Tissue Donors
Transplants*
Visual Acuity