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Acute antibody-mediated rejection limited to medullary lesions in following ABO-incompatible living donor kidney transplantation

Kim AY, Cho KH, Park JW, Do JY, Han MH, Kim YJ, Kang SH

Anatomical differences between the renal cortex and medulla may influence inflammatory responses. Owing to the difficulty in diagnosing rejections from the medulla, rejection is usually diagnosed through the cortex. However,...
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Clinical significance of de novo donor-specific antibody in kidney transplant recipients with chronic antibody-mediated rejection

Park WY, Kim Y, Paek JH, Jin K, Han S

Background: Chronic antibody-mediated rejection (CABMR) is an important cause of late graft loss. De novo donor-specific antibody (dnDSA) is an important prognostic factor for long-term allograft outcomes. However, the prognosis...
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Descemet Stripping Automated Endothelial Keratoplasty for Repeated Penetrating Keratoplasty Graft Failure

Hwang GD, Yun HY, Ha MJ, Whang WJ, Chang DJ, Hwang HS, Na KS

Purpose: To report a case of Descemet stripping automated endothelial keratoplasty (DSAEK) for graft failure after re-penetrating keratoplasty (PK). Case summary: A 33-year-old man of Indian nationality who had developed right...
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FAS-670A>G gene polymorphism and the risk of allograft rejection after organ transplantation: a systematic review and meta-analysis

Eslami MM, Rezaei R, Abdollahi S, Davari A, Ahmadvand M

The association between the risk of allograft rejection after organ transplantation and FAS gene polymorphism has been evaluated previously. However, inconsistent results have been reported. Hence, we conducted the most...
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Pediatric heart transplantation: how to manage problems affecting long-term outcomes?

Kim YH

Since the initial International Society of Heart Lung Transplantation registry was published in 1982, the number of pediatric heart transplantations has increased markedly, reaching a steady state of 500–550 transplantation...
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Heart Transplant Immunosuppression Strategies at Cedars-Sinai Medical Center

Chang DH, Youn JC, Dilibero D, Patel JK, Kobashigawa JA

Heart transplant is the optimal treatment for selected patients with end-stage heart failure. Immunosuppression after heart transplantation has significantly reduced the incidence of rejection and improved patient outcomes with the...
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Double trouble: concurrent cytomegalovirus and BK polyomavirus infections in a patient who underwent kidney transplantation

Mah DY, Azlin A, Gnanasegaram HK, Zaimi M, Yahya R

A 19-year-old student, who had received a kidney from her mother and had moderate cytomegalovirus (CMV) infection risk, received triple immunosuppression (IS) with corticosteroids, tacrolimus, and mycophenolate sodium (MPS). The...
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Successful ABO-incompatible living donor liver transplantation using splenectomy and intravenous immunoglobulin in high isoagglutinin titer patients

Lee B, Cho JY, Lee HW, Choi Y, Yoon YS, Han HS

The role of the isoagglutinin (IA) titer in liver transplantation (LT) is still not well defined, but the general belief is that a higher titer may result in a higher...
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Mycophenolic Acid Trough Concentration and Dose Are Associated with Hematologic Abnormalities but Not Rejection in Kidney Transplant Recipients

Jung HY, Lee S, Jeon Y, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD

Background: Little is known regarding the safe fixed dose of mycophenolic acid (MPA) for preventing biopsy-proven acute rejection (BPAR) in kidney transplant recipients (KTRs). We investigated the correlation of MPA...
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Effect of everolimus rescue therapy for acute cellular rejection following pediatric living donor liver transplantation: Report of one case

Hwang S, Namgoong J, Oh SH, Kim KM, Ahn CS, Kwon H, Cho YJ, Kwon YJ

Acute cellular rejection (ACR) after pediatric living donor liver transplantation (LDLT) is often curable with steroid pulse therapy, but a few pediatric patients show steroid-resistant ACR, which is difficult to...
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The Effects of Intrapatient Variability in Tacrolimus Concentration on Clinical Outcomes Immediately After Liver Transplantation

Kim E, Kim B, Cho J, Lee JH, Lee E, Yu YM, Cho JY, Lee E, Choi Y

Background: Tacrolimus, a calcineurin inhibitor, is an immunosuppressant used in post-transplantation maintenance therapy. The drug has a narrow therapeutic range and requires periodic therapeutic drug monitoring. Although many studies have...
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Diagnosis of renal transplant rejection: Banff classification and beyond

Jeong HJ

Diagnosis of renal transplant rejection is dependent on interpretation of renal allograft biopsies. The Banff Classification of Allograft Pathology, which was developed as a standardized working classification system in 1991,...
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Immunological Characteristics and Management of Kidney Transplantation

Kim MG

Kidney transplantation (KT) is the best way to improve the quality of life and survival of patients with end-stage renal disease. However, after KT the adaptive immune system plays important...
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Neutrophil-to-lymphocyte ratio predicts early acute cellular rejection in living donor liver transplantation

Lee B, Choi Y, Cho JY, Yoon YS, Han HS

Purpose: The aim of this study was to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) in acute cellular rejection (ACR) after living donor liver transplantation (LDLT). Methods: All consecutive patients...
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Immunologic strategies and outcomes in ABO-incompatible living donor liver transplantation

Oh J, Kim JM

Antibody mediated rejection (AMR) after adult ABO-incompatible living donor liver transplantation (ABO-I LDLT) induced hepatic necrosis or diffuse intrahepatic biliary complications, which were related with poor graft and patient survival....
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Clinical significance of donor-specific anti-HLA-DR51/52/53 antibodies for antibody-mediated rejection in kidney transplant recipients

Park BG, Park Y, Joo DJ, Huh KH, Kim MS, Kim SI, Kim YS, Kim HS

BACKGROUND: The presence of donor-specific antibodies (DSAs) to human leukocyte antigen (HLA) increases the risk of antibody-mediated rejection (ABMR) after kidney transplantation (KT). However, the clinical relevance of anti-HLA-DR51/52/53 antibodies...
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ABO-incompatible liver transplantation using only rituximab for patients with low anti-ABO antibody titer

Lee B, Choi Y, Han HS, Yoon YS, Cho JY, Jeong SH, Kim JW, Jang ES, Ahn S

BACKGROUNDS/AIMS: Graft survival after ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has increased due to advances in desensitization methods. We analyzed early outcomes following ABOi LDLT using only rituximab without...
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Association of Newly Developed Right Bundle Branch Block with Graft Rejection Following Heart Transplantation

Kim JH, Oh J, Kim MJ, Kim IC, Uhm JS, Pak HN, Kang SM

PURPOSE: We aimed to examine associations between right bundle branch block (RBBB) following heart transplantation (HT) and graft rejection. MATERIALS AND METHODS: We investigated 51 patients who underwent endomyocardial biopsies, electrocardiogram,...
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Comparison of Transplant Outcomes for Low-level and Standard-level Tacrolimus at Different Time Points after Kidney Transplantation

Jung HY, Cho SY, Choi JY, Cho JH, Park SH, Kim YL, Kim HK, Huh S, Won DI, Kim CD

BACKGROUND: Optimal tacrolimus (TAC) trough levels for different periods after kidney transplantation (KT) has not been definitely established. This study aimed to investigate transplant outcomes of low-level (LL) and standard-level...
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Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy

Ko EJ, Yu JH, Yang CW, Chung BH

BACKGROUND/AIMS: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV...
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