J Korean Soc Plast Reconstr Surg.  1999 Sep;26(5):991-995.

Clinical Application of Artificial Edrmis (terudemis) for Exposed Tendon and Bone Area

• Lee HS
• Lee CJ
• Gil MS
• Lee SI

Abstract

Local or distant flap surgery has been applied in the soft tissue defect area where bone and tendon are exposed, but there are many pitfalls in these surgeries including limitation of donor site selection, as well as functional and aesthetic dissatisfaction of the donor and recipient site. So these problems have facilitated the development and study of skin substitute (artificial dermis). The history of artificial skin began in the 1980s with the invention of Stage I membrane by Yannas and Burke. Since then it has been developed and applied to chinical cases of extensive burn injury and soft tissue defect. In 1989, and artificial dermis (Terudermis) composed of fibrillar collagen and heat denaturated atelocollagen was developed by Konish. It has the advantage of allowing early-incorporation of cellular and vascular components into its collagen sponge, as well as dehydrothermal cross-linking, which is very weak. This study included 18 consecutive cases which underwent application of artificial dermis on bone and tendon from January 1997 to November 1998. The exposed areas were the result of trauma in 10 cases, postoperative complications in 2 cases, and other causes in 6 cases. The follow-up period ranged from 3 months to 18 months, averaging 11 months. A week after wound debridement and Terudermis application, neovascularization had begun and granulation tissue appeared aften 2-3 weeks. Then the split or full -thickness skin graft was secondarily applied resulting in the production of sufficient skin. In conclusion, Terudermis application to an area of exposed bone and tendon is a very useful method, especially when primary local or distant flap surgery cannot be used. This method is very simple, convenient and reliable.

MeSH Terms

Burns
Collagen
Debridement
Dermis
Fibrillar Collagens
Follow-Up Studies
Granulation Tissue
Hot Temperature
Humans
Inventions
Membranes
Porifera
Postoperative Complications
Skin
Skin, Artificial
Tendons*
Tissue Donors
Transplants
Wounds and Injuries
Collagen
Fibrillar Collagens