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Association of COVID-19 vaccination and COVID-19 infection risk in heart transplantation recipients

Yoo S, Kim SE, Oh J, Jung J, Lee K, Lee CJ, Kang SM

Background: Orthotopic heart transplant (OHT) recipients are vulnerable to SARS-CoV-2 (COVID-19) infection. However, there are few studies studying the clinical impact of COVID-19 vaccination in OHT patients. We aimed to...
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The predictive role of absolute lymphocyte counts for fatal infection in heart transplantation recipients who received induction therapy

Kim SE, Oh J, Lee CJ, Kang SM

Background: The induction therapy for heart transplantation (HT) recipients could reduce the rejection risk. However, induction therapy also increases fatal infection risk by decreasing the absolute lymphocyte count (ALC). We...
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Betulin, an Anti-Inflammatory Triterpenoid Compound, Regulates MUC5AC Mucin Gene Expression through NF-kB Signaling in Human Airway Epithelial Cells

Hossain R, Kim Ki, Jin F, Lee HJ, Lee CJ

Betulin is a triterpenoid natural product contained in several medicinal plants including Betulae Cortex. These medicinal plants have been used for controlling diverse inflammatory diseases in folk medicine and betulin...
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Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus

Kim S, Kim J, Park YM, Suh PG, Lee CJ

  • KMID: 2535064
  • Exp Neurobiol.
  • 2022 Oct;31(5):332-342.
  • doi: 10.5607/en22033
Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in...
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Can Artificial Intelligence Change the Practice of Managing Hypertension?

Kim SE, Lee CJ

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Involvement of IKK/IkBα/NF-kB p65 Signaling into the Regulative Effect of Engeletin on MUC5AC Mucin Gene Expression in Human Airway Epithelial Cells

Hossain R, Kim Ki, Li X, Lee HJ, Lee CJ

In this study, we examined whether engeletin exerts an effect on the gene expression of MUC5AC mucin, in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with engeletin for...
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Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice

Sa M, Lee JM, Park MG, Lim J, Joseph Kim JM, Koh W, Yoon BE, Lee CJ

  • KMID: 2531118
  • Exp Neurobiol.
  • 2022 Jun;31(3):147-157.
  • doi: 10.5607/en22014
The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus...
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Elevated On-Treatment Diastolic Blood Pressure and Cardiovascular Outcomes in the Presence of Achieved Systolic Blood Pressure Targets

Kim DH, Cho IJ, Kim W, Lee CJ, Kim HC, Shin JH, Kang SH, Jung MH, Kwon CH, Lee JH, Kim HL, Kim HM, Cho I, Kang DR, Lee HY, Chung WJ, Kim KI, Cho EJ, Sohn IS, Park S, Shin J, Ryu SK, Kang SM, Pyun WB, Cho MC, Kim JH, Lee JH, Ihm SH, Sung KC

Background and Objectives: This study aimed to investigate the association between cardiovascular events and 2 different levels of elevated on-treatment diastolic blood pressures (DBP) in the presence of achieved systolic...
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Contemporary Unplanned Readmission Trends Following Management of Type B Aortic Dissection

Williamson AJ, Sankary S, Kuchta KM, Gaines S, Morcos O, Lind B, Pocivavsek L, Dua A, Lee CJ

Purpose: Large studies have demonstrated improved survival outcomes with thoracic endovascular aortic repair (TEVAR) at two and five years compared to medical therapy; however, early TEVAR for acute type B...
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The Paradox in Defining Obesity in Patients With Heart Failure

Kim SE, Lee CJ

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Prognostic Value of Short-Term Followup of Multiple Biomarkers After Discharge in Hospitalized Patients With Acute Heart Failure (POSTBIO-HF): Rationale and Study Design

Cho DH, Son JW, Lee CJ, Choi J, Kim MN, Lee JH, Lee S, Yang DH, Cho HJ, Choi JO, Kim EJ, Choi DJ, Yoo BS

Several surrogate biomarkers possess prognostic significance for heart failure (HF), and a decline in their respective values may predict clinical improvement. However, data on the prognostic value of these biomarkers...
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Small Molecule Drug Candidates for Managing the Clinical Symptoms of COVID-19: a Narrative Review

Yun C, Lee HJ, Lee CJ

Towards the end of 2019, an atypical acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and subsequently named Coronavirus disease 2019...
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Eriodictyol Inhibits the Production and Gene Expression of MUC5AC Mucin via the IκBα-NF-κB p65 Signaling Pathway in Airway Epithelial Cells

Yun C, Lee HJ, Lee CJ

In this study, we investigated whether eriodictyol exerts an effect on the production and gene expression of MUC5AC mucin in human pulmonary epithelial NCI-H292 cells. The cells were pretreated with...
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A Deafness Associated Protein TMEM43 Interacts with KCNK3 (TASK-1) Two-pore Domain K+ (K2P) Channel in the Cochlea

Jang MW, Kim TY, Sharma K, Kwon J, Yi E, Lee CJ

  • KMID: 2522145
  • Exp Neurobiol.
  • 2021 Oct;30(5):319-328.
  • doi: 10.5607/en21028
The TMEM43 has been studied in human diseases such as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5) and auditory neuropathy spectrum disorder (ANSD). In the heart, the p.(Ser358Leu) mutation has...
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Heart Failure Statistics in Korea, 2020: A Report from the Korean Society of Heart Failure

Park JJ, Lee CJ, Park SJ, Choi JO, Choi S, Park SM, Choi EY, Kim EJ, Yoo BS, Kang SM, Park MH, Lee J, Choi DJ

Background and Objectives: Heart failure (HF) is a disease with high morbidity and mortality. With ageing society and increasing prevalence of risk factors of HF, the prevalence of HF is...
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Differential Cellular Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus Monkey

An H, Cho DW, Lee SE, Yang YS, Han SC, Lee CJ

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Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease

An H, Lee H, Yang S, Won W, Lee CJ, Nam MH

  • KMID: 2517475
  • Exp Neurobiol.
  • 2021 Jun;30(3):222-231.
  • doi: 10.5607/en21013
Parkinson’s disease (PD) is the most prevalent neurodegenerative motor disorder. While PD has been attributed to dopaminergic neuronal death in substantia nigra pars compacta (SNpc), accumulating lines of evidence have...
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Differential Proximity of Perisynaptic Astrocytic Best1 at the Excitatory and Inhibitory Tripartite Synapses in APP/PS1 and MAOB-KO Mice Revealed by Lattice Structured Illumination Microscopy

An H, Koh W, Kang S, Nam MH, Lee CJ

  • KMID: 2517474
  • Exp Neurobiol.
  • 2021 Jun;30(3):213-221.
  • doi: 10.5607/en21015
Bestrophin-1 (Best1) is a GABA- and glutamate-permeable, Ca 2+ -activated Cl - channel, which is mainly expressed in astrocytes and localized at the microdomain or perisynaptic junction of the tripartite...
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An Atypical Choroid Plexus Papilloma Initially Manifestating as Radicular Symptoms

Lee CJ, Kim JH, Kim Y, Lee JB, Ryu B

A 29-year-old woman had 1-month history of back pain radiating into lower extremities, motor weakness, and sensory abnormalities in both lower extremities. Contrast-enhanced spinal magnetic resonance imaging (MRI) revealed a...
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Insights on Bridging Stent Grafts in Fenestrated and Branched Aortic Endografting

Yoon WJ, Rodriguez VM, Lee CJ

Major branches of the aortic arch and visceral aorta pose a particular challenge for endovascular repair of aneurysms involving these regions. To preserve perfusion through these essential branches, fenestrated and...
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