J Korean Soc Transplant.
2005 Jun;19(1):63-68.
A Case of Nocardiosis with CMV (Cytomegalovirus) Infection after Third Renal Transplantation in China
- Affiliations
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- 1Department of Internal Medicine, Bong seng Hospital, Busan, Korea. kidney119@yahoo.co.kr
- 2Department of Clinical Pathology, Bong seng Hospital, Busan, Korea.
Abstract
- It has been well known that long-term immune suppression in renal transplant patients increases the possibility of complications. Infectious disease is one of the representative complications. We experienced a case of nocardiosis with cytomegalovirus infection after third renal transplantation in China. Nocardiosis is an important opportunistic infection in immunosuppressed patients, lymphoma, sarcoidosis, and organ transplant patients. CMV can cause severe hepatitis, pneumonitis, enteritis, endometritis, and encephalitis. It can depress bone marrow, and impair the immune system so as to increase other bacterial infection and trigger rejections. Third renal transplantation causes long-term immune suppression or over-immune suppression on transplant patients. Very few cases of third renal transplantation have been reported in Korea. We reduced the dose of immune- suppressants, and treated it successfully with ganciclovir and Trimethoprim/Sulfamethoxazole (Bactrim(R)).
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