The Effect of Fentanyl-Ketorolac-Droperidol and Nalbuphine-Ketorolac-Droperidol for Postoperative Analgesia in Cesarean Section Patients

Lee, Jae Sang; Cheong, Young Pyo; Lee, Kang Chang; Kim, Tai Yo

Abstract

Opioids produce strong analgesic effect result with some side effects such as nausea, vomiting, urinary retention, somnolence, and respiratory depression. Nalbuphine, an agonist-antagonist has, at low doses, an analgesic potency comparable to morphine with little side effects. Analgesic effect after continuous infusion of fentanyl-ketorolac-droperidol, or Nubain(R)-ketorolac-droperidol combination in Cesarean section patients were assessed by numerical rating scale (NRS) and Prince Hednry scale (PHS), The patients were divided into two groups. Each group consists of 30 patients. Group l received 20 microgram of fentanyl the end of surgery. And then continuously infused with additional 380 microgram of fentanyl plus l20 mg of ketorolac and 2.5 mg of droperidol. Group 2 initially received 2 mg of Nubain(R) at the end of surgery and the remaining dose of Nubain(R) 38 mg plus ketorolac 120 mg and droperidol 2.5 mg was continuously infused. With all patients, initial dose of drug was administered by bolus of i.v. injection and the remaining dose was administered via i.v. using a Baxter Two InfusorR. Pain scores and side effects were recorded at the time of recovery room arrival, and at interval of 30 min, 1 hr, 6 hr, l2 hr, 24 hr, 48 hr after start of continuous infusion. No significant difference was found between the pain scores and side effects of both groups although pain control effect was excellent in both groups. We concluded that Nubain(R) could be an alternative to fentanyl for postoperative pain control.