J Liver Cancer.  2016 Mar;16(1):63-66. 10.17998/jlc.2016.16.1.63.

A Case of Complete Remission in Patient with Extrahepatic Metastasis after Curative Resection of Hepatocellular Carcinoma by Radiotherapy, Lung Resection and Systemic Chemotherapy

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. dyk1025@yuhs.ac
  • 2Yonsei Liver Center, Severance Hospital, Seoul, Korea.
  • 3Department of Radiologic Oncology, Yonsei University College of Medicine, Seoul, Korea.


Surgical resection is mainstay treatment of hepatocellular carcinoma (HCC). However, its prognosis is poor, because of the high incidence of HCC recurrence (cumulative 5-year HCC recurrence rate of 70-80%). The most common site of HCC recurrence is the remnant liver, and extrahepatic recurrence occurs in 6.7-13.5% of patients. Because the tumor characteristics in extrahepatic recurrence are usually multiple and aggressive, the optimal treatment modality has not yet been determined. We report a case of complete remission and long term survival over 60 months in patient with extrahepatic metastasis after curative resection of HCC by aggressive treatment, which include lung resection for lung metastasis, radiotherapy for mediastinal lymph node metastasis, and systemic chemotherapy.


Hepatocellular carcinoma; Extrahepatic metastasis; Metastasectomy; Radiotherapy; Chemotherapy
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