J Korean Neurosurg Soc.  2011 Nov;50(5):457-459. 10.3340/jkns.2011.50.5.457.

De Novo Aneurysm after Treatment of Glioblastoma

Affiliations
  • 1Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Incheon, Korea.
  • 2Department of Neurosurgery, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea. hongyk@catholic.ac.kr

Abstract

A rare case of spontaneous subarachnoid hemorrhage from newly developed cerebral aneurysm in glioblastoma patient is presented. A 57-year-old man was presented with headache and memory impairment. On the magnetic resonance image and the magnetic resonance angiography, a large enhancing mass was found at right frontal subcortex and intracranial aneurysm was not found. The mass was removed subtotally and revealed as glioblastoma. He took concurrent PCV chemotherapy and radiation therapy, but the mass recurred one month later after radiotherapy. He was then treated with temozolomide for 7 cycles. Three months after the completion of temozolomide therapy, he suffered from a subarachnoid hemorrhage due to a rupture of a small de novo aneurysm at distal anterior cerebral artery. He underwent an aneurysm clipping and discharged without neurologic complication.

Keyword

Glioblastoma; Intracranial aneurysm; Subarachnoid hemorrhage; Radiation therapy; Chemotherapy

MeSH Terms

Aneurysm
Anterior Cerebral Artery
Dacarbazine
Glioblastoma
Headache
Humans
Intracranial Aneurysm
Magnetic Resonance Angiography
Magnetic Resonance Spectroscopy
Memory
Middle Aged
Rupture
Subarachnoid Hemorrhage
Dacarbazine
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