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Modulation of Autophagy is a Potential Strategy for Enhancing the Anti-Tumor Effect of Mebendazole in Glioblastoma Cells

Jo SB, Sung SJ, Choi HS, Park JS, Hong YK, Joe YA

Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has been suggested as a repositioning candidate for the treatment of brain tumors. However, the efficacy...
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Engineered Aurotherapy for the Multimodal Treatment of Glioblastoma

Kim HS, Lee DY

Glioblastoma multiforme (GBM) is the most aggressive brain tumor, characterized by fatal prognosis and high rates of recurrence. Although there are various treatment strategies such as surgical resection, radiotherapy, and...
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Proteomics of Extracellular Vesicle in Glioblastoma

Lee YJ, Seo CW, Lee D, Choi D

Glioblastoma multiforme (GBM), a high-grade astrocytic brain tumor, has highly aggressive and heterogeneous phenotypes with active cellular invasion, angiogenesis, and immune system modulation in the tumor microenvironment driven by complex...
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Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review

Jang C, Cho BK, Hwang SH, Shin HJ, Yoon SH

Approximately two-thirds of glioblastoma (GBM) patients progress to leptomeningeal spread (LMS) within two years. While 90% of LMS cases are diagnosed during the progression and/or recurrence of GBM (defined as...
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Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Ahn J, Shin C, Kim YS, Park JS, Jeun SS, Ahn S

Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have...
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EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome

da Costa BHB, Becker AP, Neder L, Gonçalves PG, de Oliveira C, Polverini AD, Clara CA, Teixeira GR, Reis RM, Bidinotto LT

Background: Despite the advances in glioblastoma (GBM) treatment, the average life span of patients is 14 months. Therefore, it is urgent to identity biomarkers of prognosis, treatment response, or development...
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Recent Advances in Cancer Imaging with 64 CuCl2 PET/CT

Peng F

Copper is required for cancer cell proliferation and tumor angiogenesis. Radioactive copper-64 chloride ( 64 CuCl2 ) is a useful radiotracer for cancer imaging with position emission tomography (PET) based...
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Added Value of Contrast Leakage Information over the CBV Value of DSC Perfusion MRI to Differentiate between Pseudoprogression and True Progression after Concurrent Chemoradiotherapy in Glioblastoma Patients

Pak E, Choi SH, Park CK, Kim TM, Park SH, Won JK, Lee JH, Lee ST, Hwang I, Yoo RE, Kang KM, Yun TJ

Purpose: To evaluate whether the added value of contrast leakage information from dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) is a better prognostic imaging biomarker than the cerebral blood...
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Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses

Şenkesen , Tezcanlı E, Abacıoğlu MU, Özen Z, Çöne D, Küçücük H, Göksel EO, Arifoğlu A, Şengöz M

Objective: This study aimed to investigate the tumor volume changes occurring during limited-field radiotherapy (RT) for glioblastoma patients and whether a volume-adapted boost planning approach provided any benefit on tumor...
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Radiotherapy for Newly Diagnosed Glioblastoma in the Elderly: What Is the Standard?

Wee CW

Nearly half of the patients with newly diagnosed glioblastomas are aged ≥65 years. Unfortunately, these elderly patients with glioblastoma (GBM-e) demonstrate detrimental survival. However, the optimal treatment for GBM-e after...
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Current Immunotherapeutic Approaches for Malignant Gliomas

Han MH, Kim CH

Glioblastoma is the most common malignant central nervous system (CNS) tumor (48.3%), with a median survival of only about 14.6 months. Although the CNS is an immune-privileged site, activated T...
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Detection of TERT Promoter Mutations Using Targeted Next-Generation Sequencing: Overcoming GC Bias through Trial and Error

Lee H, Lee B, Kim DG, Cho YA, Kim JS, Suh YL

Purpose Detection of telomerase reverse transcriptase (TERT) promoter mutations is a crucial process in the integrated diagnosis of glioblastomas. However, the TERT promoter region is difficult to amplify because of...
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Analysis of the Cancer Genome Atlas Data to Determine the Prognostic Value of GABPB1L and TERT in Glioblastoma

Kim J, Jung SJ, Lee JH

Glioblastoma multiforme (GBM) is the most lethal type of brain tumor and its prognosis was extremely poor. Here, we studied the clinical and prognostic value of telomerase reverse transcriptase (TERT)...
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Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas

Samman DME, Mahdy MME, Cousha HS, Kamar ZAER, Mohamed KAK, Gabal HHA

Background: Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1)...
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Synthesis of New Boron Derived Compounds; Anticancer, Antioxidant and Antimicrobial Effect in Vitro Glioblastoma Tumor Model

Koldemir-Gündüz M, Aydin HE, Berikten D, Kaymak G, Köse DA, Arslantaş A

Objective : The aim of our study is to investigate the cytotoxic, antioxidant, and antimicrobial effects of newly synthesized boron compounds in U87MG glioblastoma cell treatment. Methods : We synthesized boron...
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Effect of Cadherin-11 Expression on the Prognosis of a Newly Diagnosed Primary Glioblastoma

Seo H, Lee HW, Yoon SY, Chang SH, Park SH, Hwang JH, Park TI, Park KS

Background Cadherin-11, a cell-to-cell adhesion molecule, is associated with higher tumor grade and decreased patient survival. The purpose of this study was to investigate the clinical significance of cadherin-11 expression...
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Influence of the Amount of Fresh Specimen on the Isolation of Tumor Mesenchymal Stem-Like Cells from High-Grade Glioma

Kong SH, Yoo J, Lee D, Moon S, Sung KS, Park SH, Shim JK, Choi RJ, Yoon SJ, Moon JH, Kim EH, Lee SJ, Chang JH, Kang SG

Purpose: A critical indicator of the overall survival of patients with high-grade glioma is the successful isolation of tumor mesenchymal stem-like cells (tMSLCs), which play important roles in glioma progression....
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Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells

Song Q, Peng S, Sun Z, Heng X, Zhu X

Purpose: Temozolomide is used in first-line treatment for glioblastoma. However, chemoresistance to temozolomide is common in glioma patients. In addition, mechanisms for the anti-tumor effects of temozolomide are largely unknown....
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Propranolol Inhibits the Proliferation of Human Glioblastoma Cell Lines through Notch1 and Hes1 Signaling System

Kim HS, Park YH, Lee HS, Kwon MJ, Song JH, Chang IB

Objective : The anti-tumor effect of the beta-adrenergic receptor antagonist propranolol in breast cancer is well known; however, its activity in glioblastoma is not well-evaluated. The Notch-Hes pathway is known...
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Prediction of Prognosis in Glioblastoma Using Radiomics Features of Dynamic Contrast-Enhanced MRI

Pak E, Choi KS, Choi SH, Park CK, Kim TM, Park SH, Lee JH, Lee ST, Hwang I, Yoo RE, Kang KM, Yun TJ, Kim JH, Sohn CH

Objective: To develop a radiomics risk score based on dynamic contrast-enhanced (DCE) MRI for prognosis prediction in patients with glioblastoma. Materials and Methods: One hundred and fifty patients (92 male [61.3%];...
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