J Korean Med Assoc.  2006 Feb;49(2):181-186. 10.5124/jkma.2006.49.2.181.

Aspirin for the Prevention of Cardiovascular Events

• Lee CW

• KMID: 2184666
• DOI: http://doi.org/10.5124/jkma.2006.49.2.181

Abstract

Plaque disruption and subsequent thrombotic occlusion is the primary mechanism by which atherosclerosis leads to acute coronary syndromes and ischemic stroke. Platelets are the key component of arterial thrombus formation in response to sudden fissuring or rupture of the atheromatous plaque. Low dose aspirin (100~300 mg/day) rapidly inhibits platelets through permanent inactivation of the key platelet enzyme, cyclooxygenase (COX). The efficacy and safety of aspirin have been extensively studied in several populations, ranging from healthy individuals to highrisk patients with acute myocardial infarction or ischemic stroke. It is well established that aspirin reduces the risk of serious vascular events (death, myocardial infarction, and stroke) by approximately 25% in patients with established vascular diseases. However, long-term therapy with aspirin approximately doubles the risk of major extracranial bleeding (mostly gastrointestinal bleeding) and also increases the risk of hemorrhagic stroke. In contrast to the clear benefit of aspirin in secondary prevention, its benefits in primary prevention are less clear. A meta-analysis of primary prevention trials in men demonstrated that aspirin reduces the risk of myocardial infarction by approximately 30% but has no effects on the risk of stroke. By contrast, the Women's Health Study showed that aspirin reduces the risk of stroke by 17% but has no effects on the risk of myocardial infarction. The reasons for this discrepancy remain unclear, requiring additional studies. Taken together, aspirin is recommended for primary prevention in healthy individuals with an annual risk of vascular events >1.5%. In conclusion, aspirin is recommended for secondary prevention in all patients, but its risk-benefit ratio should be carefully considered for primary prevention.

Keyword

Aspirin; Primary prevention; Secondary prevention

MeSH Terms

Acute Coronary Syndrome
Aspirin*
Atherosclerosis
Blood Platelets
Hemorrhage
Humans
Male
Myocardial Infarction
Primary Prevention
Prostaglandin-Endoperoxide Synthases
Rupture
Secondary Prevention
Stroke
Thrombosis
Vascular Diseases
Women's Health
Aspirin
Prostaglandin-Endoperoxide Synthases

Figure

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  Figure 1 Aspirin for the primary prevention of myocardial infarction

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  Figure 2 Asprin for stroke prevention

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  Figure 3 Suggested algorithm for the use of aspirin for primary prevention

Reference

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3. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet. 2001. 357:89–95.

4. Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med. 2005. 352:1293–1304.