J Breast Cancer.  2005 Mar;8(1):62-67. 10.4048/jbc.2005.8.1.62.

Prognostic Factors Predicting the Survival of Breast Cancer Patients with Metastases or Recurrences: Clinicopathologic Characteristics of Primary Tumor

• Chang ED
• Lee EJ
• Oh SJ
• Kim JS
• Kang CS

• KMID: 2174923
• DOI: http://doi.org/10.4048/jbc.2005.8.1.62

Abstract

PURPOSE
This study was conducted to evaluate the relationship of the biological parameters for survival after tumor recurrence or metastases for breast cancer patients. METHODS: Fifty patients with local recurrence or distant metastases after their treatment for breast cancer were selected for our study. RESULTS: These patients constituted 16.9% (50/296) of all the patients with breast cancer who were treated during the investigation period. Survival was correlated with the lymph node status (p = 0.036) and the disease free interval (DFI) (p < 0.001), but patient survival was not correlated with the patient's age (p = 0.586), the tumor type (p = 0.360), tumor grade (p = 0.353), tumor size (p = 0.886), extensive intraductal component (EIC) (p = 0.295), lymphatic invasion (p = 0.880), estrogen receptor (ER) status (p = 0.408), androgen receptor (AR) status (p = 0.386), the HER-2/neu expression (p = 0.291), the operative methods (p = 0.880), adjuvant therapy (p = 0.551) and metastatic organs and recurrence (p = 0.070). The overall median length of the DFI was 25.9 months. The 16 dead patients (32.0%) had a shorter mean DFI (19.7 months) than the mean DFI (28.8 months) of the 34 live patients (68.0%). The overall 5-year survival rate was 10.0%. CONCLUSION: We found the clinicopathological features of the presenting primary tumors that predicted a worse clinical outcome with recurrence or metastases, and these factors can be used in these types of cases as indicators for the prognosis.

Keyword

Breast carcinoma; Metastasis; prognosis; Recurrence; Survival

MeSH Terms

Breast Neoplasms*
Breast*
Estrogens
Humans
Lymph Nodes
Neoplasm Metastasis*
Prognosis
Receptors, Androgen
Recurrence*
Survival Rate
Estrogens
Receptors, Androgen