Ann Dermatol.  2016 Apr;28(2):172-178. 10.5021/ad.2016.28.2.172.

Clinical Features of Cutaneous Premalignant Lesions in Busan City and the Eastern Gyeongnam Province, Korea: A Retrospective Review of 1,292 Cases over 19 Years (1995~2013)

• Choi SH
• Kim KH
• Song KH

• KMID: 2171373
• DOI: http://doi.org/10.5021/ad.2016.28.2.172

Abstract

BACKGROUND
The global prevalence of premalignant lesions has been continuously increasing in recent years, but there has been little research regarding the distribution and incidence of cutaneous premalignant lesions in Korean populations.
OBJECTIVE
We conducted this retrospective study to analyze recent trends in the incidence and clinical patterns of cutaneous premalignant lesions in the Korean population.
METHODS
We reviewed 1,292 cases (3,651 lesions) of patients with cutaneous premalignant lesions, including actinic keratosis (AK) and Bowen's disease (BD), from the Department of Dermatology at Dong-A University Hospital (January 1995 to December 2013).
RESULTS
The average cutaneous premalignant lesion annual incidence was 1.82%, and the incidence continuously increased from 0.70% to 4.25% over the study period. The most common cutaneous premalignant lesion was AK (75.85%), followed by BD (24.15%). The mean age of onset was 68.76 years (men, 70.89 years; women, 65.56 years), and the male:female ratio of patients was 1:1.52. Major skin cancers, including squamous cell carcinoma (SCC, 8.90%), basal cell carcinoma (BCC, 6.42%), and malignant melanoma (MM, 0.70%), were detected in 15.79% of patients with cutaneous premalignant lesions. Three patients (0.23%) were previously diagnosed with both SCC and BCC. In addition, 59.13% of patients had a single lesion, while 40.87% had multiple lesions. Patient age, history of previous skin cancers, and occupation-related exposure to ultraviolet radiation were more common in patients with multiple lesions.
CONCLUSION
Cutaneous premalignant lesion incidence has gradually increased in the Korean population.

Keyword

Actinic keratosis; Bowen's disease; Incidence; Korea; Precancerous conditions

MeSH Terms

Age of Onset
Bowen's Disease
Busan*
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Dermatology
Female
Humans
Incidence
Keratosis, Actinic
Korea*
Melanoma
Precancerous Conditions
Prevalence
Retrospective Studies*
Skin Neoplasms

Figure

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  Fig. 1 Annual incidence of cutaneous premalignant lesions.

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  Fig. 2 Age distribution of patients with cutaneous premalignant lesions.

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  Fig. 3 (A) Cutaneous premalignant lesion distribution and (B) histologic type proportions.

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  Fig. 4 (A) Proportion of patients with a history of skin cancer and (B) proportions of skin cancer types.

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