Clin Psychopharmacol Neurosci.  2015 Apr;13(1):62-67. 10.9758/cpn.2015.13.1.62.

An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia

Affiliations
  • 1Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan. shiina-akihiro@faculty.chiba-u.jp
  • 2Division of Law and Psychiatry, Chiba University Center for Forensic Mental Health, Chiba, Japan.
  • 3Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Chiba, Japan.
  • 4Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • 5Department of Psychiatry, Chiba University Hospital, Chiba, Japan.
  • 6Kisarazu Hospital, Chiba, Japan.
  • 7Chiba University Center for Forensic Mental Health, Chiba, Japan.
  • 8Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

Abstract

OBJECTIVE: Schizophrenia is a mental disorder characterized by severe cognitive impairment. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. In this study, we attempted to evaluate the effect of SFN on cognitive impairment in medicated patients with schizophrenia.
METHODS
We recruited a total of 10 outpatients with schizophrenia, all of whom gave informed consent. Participants took 3 tablets of SFN, consisting of 30 mg of SFN-glucosinolate per day, for 8 weeks. Clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) and cognitive function using the Japanese version of CogState battery were evaluated at the beginning of the study and at week 8.
RESULTS
A total of 7 patients completed the trial. The mean score in the Accuracy component of the One Card Learning Task increased significantly after the trial. However, we detected no other significant changes in participants.
CONCLUSION
This result suggests that SFN has the potential to improve cognitive function in patients with schizophrenia.

Keyword

Schizophrenia; Sulforafan; Executive function; Clinical trial; CogState
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