J Bone Metab.  2015 May;22(2):83-86. 10.11005/jbm.2015.22.2.83.

A First Case of Osteomesopyknosis in Korea

• Jeoung BN
• Kim JM
• Kang GE
• Lim JH
• Kim EH
• Seo HA

• KMID: 2170092
• DOI: http://doi.org/10.11005/jbm.2015.22.2.83

Abstract

Osteomesopyknosis is a rare sclerosing bone disorder of autosomal dominant inheritance. We report a first case of osteomesopyknosis in Korea. A 16-year old girl complained of diffuse back pain for 1 year. We performed physical examination, biochemical investigations and imaging studies. A radiograph of spine revealed rugger-jersey vertebra and sandwich vertebra. Bone specific alkaline phosphatase, osteocalcin and C-terminal telopeptides of type I collagen were normal. Only an axial skeleton involvement was shown on the whole body bone scan. This patient was diagnosed to have osteomesopyknosis. Osteomesopyknosis is characterized by normal level of bone turnover marker and an axial bone involvement. Osteomesopyknosis can be occurred in Korea and needs to be considered when patients, especially young patients, suffer from back pain and have only axial osteosclerosis.

Keyword

Axial osteosclerosis; Bone disease; Back pain

MeSH Terms

Alkaline Phosphatase
Back Pain
Bone Diseases
Collagen Type I
Female
Humans
Korea
Osteocalcin
Osteosclerosis
Physical Examination
Skeleton
Spine
Wills
Alkaline Phosphatase
Collagen Type I
Osteocalcin

Figure

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  Fig. 1 Radiography of spine showing bands of sclerosis at the vertebral end plates and sclerotic change at pelvic bone. (A) Lateral radiograph of thoracic-lumbar spine (B) Lateral radiograph of lumbosacral spine (C) Anterior-posterior radiograph of the lumbosacral spine.

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  Fig. 2 Abnormal densities are not shown in skull X-ray.

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  Fig. 3 Whole body bone scan with Tc-99m hydroxymethylene diphosphonate (HDP) showing suspiciously increased uptake in vertebra and normal uptake at growth plate area. (A) Anterior image (B) Posterior image.

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