Clin Exp Reprod Med.  2015 Dec;42(4):143-148. 10.5653/cerm.2015.42.4.143.

Anti-Mullerian hormone levels as a predictor of clinical pregnancy in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer cycles in patients over 40 years of age

• Park HJ
• Lyu SW
• Seok HH
• Yoon TK
• Lee WS

• KMID: 2167477
• DOI: http://doi.org/10.5653/cerm.2015.42.4.143

Abstract

OBJECTIVE
The aim of the current study was to determine the predictive value of anti-Mullerian hormone (AMH) levels for pregnancy outcomes in patients over 40 years of age who underwent in vitro fertilization or intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles.
METHODS
We retrospectively analyzed the medical records of 188 women aged 40 to 44 years who underwent IVF/ICSI-fresh ET cycles due to unexplained infertility in the fertility center of CHA Gangnam Medical Center. Patients were divided into group A, with AMH levels <1.0 ng/mL (n=97), and group B, with AMH levels > or =1.0 ng/mL (n=91). We compared the clinical pregnancy rate (CPR) in the two groups and performed logistic regression analysis to identify factors that had a significant effect on the CPR.
RESULTS
The CPR was significantly lower in group A than group B (7.2% vs. 24.2%, p<0.001). In multivariate logistic regression analysis, AMH levels were the only factor that had a significant impact on the CPR (odds ratio, 1.510; 95% confidence interval, 1.172-1.947). The area under the receiver operating characteristic curve for AMH levels as a predictor of the CPR was 0.721. When the cut-off level of AMH was set at 1.90 ng/mL, the CPR was 6.731-fold higher in the group with AMH levels > or =1.90 ng/mL than in the group with AMH levels <1.90 ng/mL (p<0.001).
CONCLUSION
Our study showed that AMH levels were predictive of clinical pregnancy in infertility patients over 40 years of age. Further prospective studies should be conducted to validate the predictive capability of AMH levels for the outcome of clinical pregnancy.

Keyword

Aged infertility patients; Anti-Mullerian hormone; Fertilization in vitro; Pregnancy rate

MeSH Terms

Anti-Mullerian Hormone*
Cardiopulmonary Resuscitation
Female
Fertility
Fertilization in Vitro
Humans
Infertility
Logistic Models
Medical Records
Pregnancy Outcome
Pregnancy Rate
Pregnancy*
Prospective Studies
Retrospective Studies
ROC Curve
Spermatozoa*
Anti-Mullerian Hormone