Gut Liver.  2010 Mar;4(1):25-30.

A Matched Case-Control Study of a Novel Acid-Pump Antagonist and Proton-Pump Inhibitor for the Treatment of Iatrogenic Ulcers Caused by Endoscopic Submucosal Dissection

• Kim YG
• Jang BI
• Kim TN

Abstract

BACKGROUND/AIMS
Revaprazan, a novel acid-pump antagonist, and proton-pump inhibitors (PPIs) have pH-independent effects on ulcer healing. The addition of a PPI promotes the cell restitution rate as well as vessel regeneration and maturation for ulcer repair. Revaprazan is known to protect the mucosa by increasing the prostaglandin concentration.
METHODS
We reviewed the medical records of patients who underwent endoscopic submucosal dissection (ESD) for gastric neoplasia at Yeungnam University Hospital between January 2008 and May 2009. We conducted a matched case-control study to compare the healing rates effected by revaprazan and rabeprazole.
RESULTS
Each group consisted of 30 patients. The baseline characteristics did not differ significantly between the two groups. Stage S1 disease was observed in 97% and 100% of patients after 8 weeks of treatment in the revaprazan and rabeprazole groups, respectively. In the revaprazan group, only one patient had stage H2 disease: a 54-year-old man with a 5.5-cm lesion after ESD of the ulcer, type IIa early gastric cancer, and adenocarcinoma. No serious adverse effects occurred during the treatment period in either group.
CONCLUSIONS
The safety and efficacy profiles of revaprazan and rabeprazole are similar for the treatment of ESD-induced ulcers.

Keyword

Revaprazan; Rabeprazole; Proton pump inhibitors; Acid pump antagonists; Endoscopic submucosal dissection

MeSH Terms

2-Pyridinylmethylsulfinylbenzimidazoles
Adenocarcinoma
Case-Control Studies
Glycosaminoglycans
Humans
Medical Records
Middle Aged
Mucous Membrane
Proton Pump Inhibitors
Pyrimidinones
Regeneration
Stomach Neoplasms
Tetrahydroisoquinolines
Ulcer
2-Pyridinylmethylsulfinylbenzimidazoles
Glycosaminoglycans
Proton Pump Inhibitors
Pyrimidinones
Tetrahydroisoquinolines