Ann Surg Treat Res.  2014 Jun;86(6):283-288. 10.4174/astr.2014.86.6.283.

The risk factors of early recurrence after hepatectomy in hepatocellular carcinoma

• Kwon SK
• Yun SS
• Kim HJ
• Lee DS

• KMID: 2167104
• DOI: http://doi.org/10.4174/astr.2014.86.6.283

Abstract

PURPOSE
Early recurrence after hepatectomy is a well-known poor prognostic factor in patients with hepatocellular carcinoma. This study was undertaken to identify the risk factors of early recurrence in patients with hepatocellular carcinoma after hepatectomy.
METHODS
One hundred and sixty-seven patients that underwent hepatectomy for hepatocellular carcinoma from January 2005 to December 2010 were enrolled. The numbers of patients with or without early recurrence group were 40 and 127, respectively. Clinico-pathologic factors were retrospectively analyzed.
RESULTS
Potential risk factors were classified as host, tumor, or surgical factors. Of the host factors examined, lobular hepatitis activity was found to be a significant risk factor of early recurrence, and of the tumor factors, infiltrative type of gross appearance, level of preoperative AFP and worst Edmondson-Steiner grade were significant.
CONCLUSION
The present study shows that an infiltrative gross appearance, a high preoperative AFP level, high lobular hepatitis activity, and a poor Edmondson-Steiner grade are independent risk factors of early recurrence. Accordingly, patients with these risk factors should be followed closely after hepatectomy.

Keyword

Hepatocellular carcinoma; Recurrence; Hepatectomy

MeSH Terms

Carcinoma, Hepatocellular*
Hepatectomy*
Hepatitis
Humans
Recurrence*
Retrospective Studies
Risk Factors*

Figure

• 

  Fig. 1 Cumulative survivals in the early recurrence group (ER) and the nonearly recurrence group (NER).

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