Korean J Pediatr.  2016 May;59(5):242-245. 10.3345/kjp.2016.59.5.242.

Bilateral iliac and popliteal arterial thrombosis in a child with focal segmental glomerulosclerosis

Affiliations
  • 1Department of Pediatrics, Jeju National University School of Medicine, Jeju, Korea.
  • 2Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. kanghg@snu.ac.kr
  • 3Department of Surgery, Seoul National University Hospital, Seoul, Korea.
  • 4Research Coordination Center for Rare Diseases, Seoul National University Hospital, Seoul, Korea.
  • 5Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Thromboembolic complications (TECs) are clinically important sequelae of nephrotic syndrome (NS). The incidence of TECs in children is approximately 2%-5%. The veins are the most commonly affected sites, particularly the deep veins in the legs, the inferior vena cava, the superior vena cava, and the renal veins. Arterial thrombosis, which is less common, typically occurs in the cerebral, pulmonary, and femoral arteries, and is associated with the use of steroids and diuretics. Popliteal artery thrombosis in children has been described in cases of traumatic dissection, osteochondroma, Mycoplasma pneumoniae infection, and fibromuscular dysplasia. We report of a 33-month-old girl with bilateral iliac and popliteal arterial thrombosis associated with steroid-resistant NS due to focal segmental glomerulosclerosis. Her treatment involved thrombectomy and intravenous heparinization, followed by oral warfarin for 8 months. Herein, we report a rare case of spontaneous iliac and popliteal arterial thrombosis in a young child with NS.

Keyword

Iliac artery; Popliteal artery; Thrombosis; Focal segmental glomerulosclerosis; Child
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