J Korean Pediatr Soc.  1994 Sep;37(9):1317-1324.

A Case of Cerebral Infarction due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome

• Kim DW
• Park HL
• Shin SM
• Kim EM

Abstract

Focal segmental glomerulosclerosis is the renal histopathologic lesion observed in 10% of children with idiopathic nephrotic syndrome. Complications include infection, thrombosis, hypocalcemia and adverse effect of steroid use. The incidence of thrombosis reported ranges from 10~40%. The pathogenesis are changes in coagulation system, decrease of Antithrombin III, increase platelet aggregability and steroid or diuretics use. These changes take place passively as a result of increased protein synthesis and urinary loss of low molecular weight protein. We experienced a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome in a 11 year old male patient who had been hospitalized because of convulsion and semicoma. MRI showed an evolving infarct in the occipital lobe, decreased antithrombin III and increased factor VIII on coagulation factor assay. We hereby report a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome with a brief review of related literature.

MeSH Terms

Antithrombin III
Blood Coagulation Factors
Blood Platelets
Cerebral Infarction*
Child
Diuretics
Factor VIII
Glomerulosclerosis, Focal Segmental*
Humans
Hypocalcemia
Incidence
Magnetic Resonance Imaging
Male
Molecular Weight
Nephrotic Syndrome*
Occipital Lobe
Seizures
Thrombosis*
Antithrombin III
Blood Coagulation Factors
Diuretics
Factor VIII