J Korean Med Sci.  2015 Aug;30(8):1035-1041. 10.3346/jkms.2015.30.8.1035.

Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population

• Jin EH
• Lee SI
• Kim J
• Seo EY
• Lee SY
• Hur GM
• Shin S
• Hong JH

• KMID: 2164496
• DOI: http://doi.org/10.3346/jkms.2015.30.8.1035

Abstract

Gastric cancer is one of the most common cancers in the world. The aims of this study were to evaluate the association between polymorphisms in TFF gene family, TFF1, TFF2, and TFF3 and the risk of gastric cancer (GC) and GC subgroups in a Korean population via a case-control study. The eight polymorphisms in TFF gene family were identified by sequencing and genotyped with 377 GC patients and 396 controls by using TaqMan genotyping assay. The rs184432 TT genotype of TFF1 was significantly associated with a reduced risk of GC (odds ratio, [OR) = 0.45; 95% confidence interval, [CI] = 0.25-0.82; P = 0.009), more protective against diffuse-type GC (OR = 0.20; 95% CI = 0.05-0.89; P = 0.035) than GC (OR = 0.34; 95% CI = 0.14-0.82; P = 0.017) in subjects aged < 60 yr, and correlated with lymph node metastasis negative GC and diffuse-type GC (OR = 0.44; 95% CI = 0.23-0.86; P = 0.016 and OR = 0.20; 95% CI = 0.05-0.87; P = 0.031, respectively). In addition, a decreased risk of lymph node metastasis negative GC and diffuse-type GC was observed for rs225359 TT genotype of TFF1 (OR = 0.46, 95% CI = 0.24-0.88; P = 0.020 and OR = 0.21, 95% CI = 0.05-0.88; P = 0.033, respectively). These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.

Keyword

Control-case Studies; Diffuse Type; Gastric Neoplasms; Polymorphism; TFF1 Protein, Human; TFF2 Protein, Human; TFF3 Protein, Human

MeSH Terms

Adult
Aged
Biomarkers, Tumor/*genetics
Female
Genetic Markers/genetics
Genetic Predisposition to Disease/epidemiology/genetics
Humans
Incidence
Male
Middle Aged
Peptides/*genetics
Polymorphism, Single Nucleotide/genetics
Promoter Regions, Genetic/genetics
Reproducibility of Results
Republic of Korea/epidemiology
Risk Assessment/methods
Sensitivity and Specificity
Stomach Neoplasms/*epidemiology/*genetics
Tumor Suppressor Proteins/*genetics
Biomarkers, Tumor
Genetic Markers
Peptides
Tumor Suppressor Proteins